冠心病伴牙周炎患者牙周状况及龈下菌斑的研究

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (3): 138-140.

冠心病伴牙周炎患者牙周状况及龈下菌斑的研究

王磊1，张梅2，吴婷3，孙钦峰3，杨丕山3，魏奉才1

1. 山东大学齐鲁医院口腔科，济南 250012； 2. 山东医学高等专科学校口腔系，济南250002；
3. 山东大学口腔医学院牙周科，济南 250012

收稿日期:2009-09-21 出版日期:2010-03-16 发布日期:2010-03-16
通讯作者: 孙钦峰（1967- ），男，副教授，主要从事牙周疾病的临床研究。
作者简介:王磊（1978- ），男，主治医师，主要从事牙周病正畸的临床研究。
基金资助:
国家十一五科技攻关计划（2007BAI18B02）；山东省自然科学基金资助项目（Q2008C11）

Periodontal pathogens in subgingival plaque of patients with coronary atherosclerosis and periodontal disease

WANG Lei1, ZHANG Mei2, WU Ting3, SUN Qinfeng3, YANG Pishan3，WEI Fengcai1

1. Department of Stomatology, Qilu Hospital of Shandong University, Jinan 250012, China; 2. Department of Stomatology, Shandong Medical College, Jinan 250002,
China; 3. Department of Periodontology, Stomatology Hospital of Shandong University, Jinan 250012, China

Received:2009-09-21 Online:2010-03-16 Published:2010-03-16

摘要/Abstract

摘要：

目的探讨牙周炎伴有冠心病患者龈下菌斑中牙周致病菌的分布，分析慢性牙周炎对冠状动脉硬化性心脏病的影响。方法随机抽取无冠心病史慢性牙周炎患者43例,设为对照组，其中男25例、女18例；冠心病合并慢性牙周炎患者40例，设为实验组，其中男23例、女17例。记录牙周指数：探诊深度（PD）、探诊出血（BOP）、附着丧失（AL），研究两组之间牙周指数的关系；采集龈下菌斑，采用实时定量聚合酶链反应（realtime PCR）方法，检测5种常见牙周致病细菌：伴放线放线杆菌（Aa）、牙龈卟啉单胞菌（Pg）、中间普氏菌（Pi）、福赛拟杆菌（Bf）和齿垢密螺旋体（Td），分析两组细菌统计学差异。结果两组之间牙周指数BOP、PD、AL经统计学分析，P＜0.05，差异有统计学意义；两组实时定量数据经统计学处理，Pg的P均＜0.05，差异有统计学意义；Aa、Pi、Bf及Td的P均＞0.05，差异无统计学意义。结论伴有冠心病的牙周炎患者，其牙周指数均较无冠心病史牙周炎患者严重；龈下菌斑中Pg含量高的牙周炎患者冠心病的发病率高。

关键词: 牙周病；冠心病；牙周指数；龈下菌斑；实时定量聚合酶链反应

Abstract:

Objective To explore the pathogens in sub-gingival plaque of patients with coronary heart disease and periodontitis, and to discuss the relationship between periodontal disease and coronary heart disease. Methods All patients with chronic periodontitis in this study were randomly selected. Patients without coronary heart disease including 25 males and 18 females were selected as the control group and patients with coronary heart disease including 23 males and 17 females were selected as the experimental group. All patients underwent a clinical periodontal examination including probing depth (PD), bleeding probing (BOP), and attachment loss (AL). Subgingival plaque was collected. The real-time quantitative polymerase chain reaction (real-time PCR) was used to test the two groups′ subgingival plaque with five pathogens: Actinobacillus actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Bacteroides forsythus (Bf) and Treponema denticola (Td). Results There were significant differences in periodontal indexes between the two groups. In the statistical analysis for the realtime PCR of five pathogens, only the result of Pg showed a significant difference (P＜0.05). Conclusions The periodontal indexes of the experimental group were higher than those of the control group. Periodontitis patients with a high content of pg have a high incidence ofcoronary heart disease.

Key words: Periodontal disease; Coronary artery disease; Periodontal index; Subgingival plaque; Realtime polymerase chain reaction

中图分类号:

R781.4

王磊1，张梅2，吴婷3，孙钦峰3，杨丕山3，魏奉才1. 冠心病伴牙周炎患者牙周状况及龈下菌斑的研究[J]. 山东大学学报(医学版), 2010, 48(3): 138-140.

WANG Lei1, ZHANG Mei2, WU Ting3, SUN Qinfeng3, YANG Pishan3，WEI Fengcai1. Periodontal pathogens in subgingival plaque of patients with coronary atherosclerosis and periodontal disease[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(3): 138-140.

参考文献

相关文章 8

[1]	陈荟，郭泾. 猪脱细胞基质矿化支架材料的生物相容性及降解特性[J]. 山东大学学报(医学版), 2013, 51(5): 48-53.
[2]	刘文婷1，胡以俊1，陈丽2，姜广水1. 慢性牙周炎和2型糖尿病患者肠道柔嫩梭菌类群的定量分析[J]. 山东大学学报(医学版), 2013, 51(4): 100-104.
[3]	庞永志1，胡温庭2，彭凤梅3. 复方白芨胶/珍珠层粉修复兔牙槽骨缺损的实验研究[J]. 山东大学学报(医学版), 2013, 51(1): 37-.
[4]	姚丽1，孙钦峰2，杨春惠1. 子痫前期伴牙周炎患者血清TNF-α、IL-6及CRP水平的检测[J]. 山东大学学报(医学版), 2012, 50(10): 123-126.
[5]	宗敏1，方冬冬1，高慧2，张君2,3. 正畸-牙周联合治疗中重度牙周炎早期牙周状况及龈沟液骨钙素水平变化的研究[J]. 山东大学学报(医学版), 2012, 50(1): 113-116.
[6]	刘梅1，张君2，王旭霞3. T1DM、T2DM糖尿病大鼠牙槽骨骨密度变化的相关性实验研究[J]. 山东大学学报(医学版), 2011, 49(9): 53-.
[7]	李雪1,林志勇1,赵芬1,赵民1,季梅1,于桂娜2，牟文丽3. 清热滋阴活血复方对大鼠糖尿病牙周炎的治疗作用及外周血IL-1β的影响[J]. 山东大学学报(医学版), 2010, 48(5): 72-74.
[8]	田李静1，2，梅银生1，2，张文娟3，张君1，王智1. 黄连水煎剂漱口对固定正畸患者牙龈炎症的影响[J]. 山东大学学报(医学版), 2009, 47(11): 111-113.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed