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山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (3): 83-85.

• 论文 • 上一篇    下一篇

分子影像标记物叶酸受体α在胰腺癌中的表达及意义

郑洪民   

  1. 黑龙江省医院放射线科, 哈尔滨 150036
  • 收稿日期:2009-11-16 出版日期:2010-03-16 发布日期:2010-03-16
  • 作者简介:郑洪民(1965- ),男,副主任医师,主要从事肿瘤分子影像研究。

Expression of molealar imaging marker folate receptor alpha in pancreatic cancer and its significance

ZHENG Hong-min   

  1. Department of Radiology, Heilongjiang Provincial Hospital, Harbin 150036, China
  • Received:2009-11-16 Online:2010-03-16 Published:2010-03-16

摘要:

目的    观察叶酸受体α(folate receptor alpha,FOLR1)在胰腺癌中的表达水平,为叶酸受体α靶向性分子显像技术的建立提供依据。方法    采用免疫印迹和免疫组织化学法检测叶酸受体α在胰腺癌、正常胰腺、癌旁和慢性胰腺炎症组织的表达,并评价其表达水平与胰腺癌临床病理学指标的关系。结果    叶酸受体α在94.7%(72/76)的胰腺癌中阳性表达,且表达水平与肿瘤转移相关,而在正常胰腺中无表达。结论    以叶酸受体α为靶点的分子影像技术在胰腺癌的诊断中可能具有良好的应用价值。

关键词: 胰腺肿瘤;分子影像;叶酸受体

Abstract:

Objective    To observe expression of folate receptor α in pancreatic cancer in order to evaluate its utility as a molecular imaging target for pancreatic cancer magnetic resonance (MR) diagnosis.  Methods    Folate receptor α expression was evaluated by immunoblot and immunohistochemistry in pancreatic cancer, normal pancreatic tissues, paratumoral and para-tumoral tissues,  and the relationship between folate receptor α expression and clinicopathological parameters was also analyzed.  Results    Folate receptor α was overexpressed in most pancreatic cancer tissues (97.4%, 72/76), but not in the normal controls. Furthermore, up-regulation of folate receptor α was associated with pancreatic cancer metastasis.  Conclusion    Folate-based contrast agents might be helpful in pancreatic cancer MR imaging.

Key words: Pancreatic cancer; Magnetic resonance; Folate receptor alpha1

中图分类号: 

  • R730.1
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