高碘对大鼠凝血功能的影响

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (1): 45-47.

高碘对大鼠凝血功能的影响

郭雪芹1，杨群2，张辉3，张娟4，边建朝5，杨晓霞5，郭成浩1

1. 山东大学医学院病理学与病理生理学研究所，济南 250012； 2. 山东大学公共卫生学院营养与食品卫生研究所，济南 250012； 3．山东大学第二医院耳鼻喉科，济南 250033；
4. 山东大学齐鲁医院病理科，济南 250012； 5. 山东省地方病防治研究所，济南 250014

收稿日期:2009-06-04 出版日期:2010-01-16 发布日期:2010-01-16
通讯作者: 郭成浩（1965- ），男，教授，主要从事病理学研究
作者简介:郭雪芹（1983- ），女，硕士研究生，主要从事病理学研究。
基金资助:
国家自然科学基金资助课题（30772134），山东省科技厅资助课题（2006BS03029）

Effect of excess iodine on coagulation function in rats

GUO Xueqin1，　YANG Qun2, ZHANG Hui3， ZHANG Juan4, BIAN Jianchao5, YANG Xiaoxia5, GUO Chenghao1

1. Institute of Pathology and Pathophysiology, School of Medicine,Shandong University, Jinan 250012, China; 2. Institute of Nutrition and Food Hygiene, School of Public Health, Shandong University, Jinan 250012, China; 3. Department of Otorhinolaryngology, Second Hospital of Shandong University, Jinan 250033, China; 4. Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012,China; 5. Shandong Institute for Endemic Disease Control and Research, Jinan 250014, China

Received:2009-06-04 Online:2010-01-16 Published:2010-01-16

摘要/Abstract

摘要：

目的建立高碘喂养的大鼠动物模型，观察不同浓度的高碘对大鼠凝血功能影响的剂量与效应关系。方法实验分4组：①正常饲料+正常水组（NI）；②正常饲料+10倍碘组（10HI）；③正常饲料+50倍碘组(50?HI)；④正常饲料+100倍碘组(100HI)；每周称体重，饲养6个月，用乙醚麻醉，从眼球静脉取血，CA7000全自动凝血分析仪测定凝血酶原时间（PT-time）、凝血酶原时间国际标准化比值（PT-INR）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原时间（Fbgtime）、纤维蛋白原浓度（Fbg-c）、抗凝血酶Ⅲ活性（AT3:A）和D-二聚体（D-dimer）。结果与NI相比，10?HI组的大鼠PT-time、PT-INR、Fbg-time、TT、APTT和AT3:A数值降低（PT、PT-INR、Fbgtime、AT3:A：P＜0.05；TT、APTT P＜0.01），Fbgc数值升高（P＜0.01）；而50HI和100HI组的大鼠PT-time、PT-INR、Fbg-time、TT、APTT数值升高(50HI组的Fbg-time、TT -P-＜0.05;50HI、100HI组的其它指标P均＜0.01)，Fbg-c数值降低（50?HI组:P＜0.05，100HI组P＜0.01)。结论适量高碘对大鼠凝血功能有促进作用，但是随着碘浓度升高，凝血功能降低。

关键词: 碘; 过量；凝血功能；大鼠，Wistar

Abstract:

Objective To observe the dose-effect relation between excess iodine and coagulation function in rats. Methods Wistar strain rats were divided into four groups: the normal diet and water group(NI), the normal diet and 10-fold iodine group(10HI), the normal diet and 50-fold iodine group(50HI), andthe normal diet and 100-fold iodine group(100HI). Body weights were determined weekly. After 6 months， blood was taken from the eyeball vein and then PT-Time, PT-INR, APTT, TT, Fbg-Time, Fbg-c, AT3:A， and D-dimer were determined by the Sysmex CA7000 automated blood coagulation analyzer. Results PT, PT-INR, Fbg-time, TT, APTT, and AT3: A were decreased while the number of Fbg-c was significantly increased in the 10HI group compared with the NI group（PT, PT-INR, Fbgtime,AT3:　A：P＜0.05： TT, APTT, Fbg-c P＜0.01） PT-time, PT-INR,　Fbg-time,　TT, and APTT significantly increased while Fbg-c significantly decreased in the 50I and 100I groups comparing with the normal control group (except for Fbg-Time, TT and Fbg-c in the 50HI group P＜0.05;the other blood coagulation indexes in the 50?HI and 100?HI groups, P＜0.01)Conclusion Appropriate excess iodine can promote blood coagulation of rats, however, with an increase of concentration of iodine, blood hypocoagulability is decreased.

Key words: Iodine; Excess; Blood coagulation; Rats, Wistar

中图分类号:

R364.1

郭雪芹1，杨群2，张辉3，张娟4，边建朝5，杨晓霞5，郭成浩1. 高碘对大鼠凝血功能的影响[J]. 山东大学学报(医学版), 2010, 48(1): 45-47.

GUO Xueqin1，　YANG Qun2, ZHANG Hui3， ZHANG Juan4, BIAN Jianchao5, YANG Xiaoxia5, GUO Chenghao1. Effect of excess iodine on coagulation function in rats[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(1): 45-47.

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