P物质、血管活性肠肽在OSAHS患者舌根组织中的表达及意义

山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (12): 105-107.

P物质、血管活性肠肽在OSAHS患者舌根组织中的表达及意义

王岩¹，李延忠¹，王卫之²

山东大学齐鲁医院 1.耳鼻咽喉科卫生部耳鼻喉科学重点实验室; 2.口腔科，济南250012

收稿日期:2009-08-20 出版日期:2009-12-16 发布日期:2009-12-16
作者简介:王岩（1966- ），女，医学硕士，副主任医师，主要从事睡眠呼吸障碍性疾病的临床与基础研究。
基金资助:
山东省科技攻关计划项目（编号2005GG4202012）。

Expressions of substance P and vasoactive intestinal peptide in tongue base tissue of patients with obstructive sleep apneahypopnea
syndrome and their significances

WANG Yan^１, LI Yanzhong１, WANG Weizhi２

1. Department of Otorhinolaryngology, Qilu Hospital of Shandong University, The Key Laboratory of Otorhinolaryngology of
Health Ministy； 2. Department of Stomtology, Qilu Hospital of Shandong University， Jinan 250012, China

Received:2009-08-20 Online:2009-12-16 Published:2009-12-16

摘要/Abstract

摘要：

目的探讨P物质及血管活性肠肽在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)舌根平面阻塞中的意义。方法通过免疫组织化学染色对49例OSAHS患者的舌根组织的P物质及血管活性肠肽的表达进行分析。结果OSAHS患者舌根组织中的粘膜下层、小血管周围、腺泡及腺导管周围均有多量P物质及血管活性肠肽表达。P物质在有舌根肥厚组阳性表达率为80.6%(25/31)，在无舌根肥厚组的阳性表达率为33.3%(6/18)，经统计学处理χ2=10.97，P=0.000?9；血管活性肠肽在有舌根肥厚组的阳性表达率为90.3%（28/31）,在无舌根肥厚组的阳性表达率为55.6%(10/18)，χ2=12.296?9，P=0.000?5，差异有统计学意义。结论OSAHS患者舌根组织中有多量P物质及血管活性肠肽表达，它们可引起局部组织肿胀并参与神经源性炎症，进而引起舌根肥厚和塌陷。

关键词: 睡眠呼吸暂停综合征，阻塞性；舌根组织；P物质；血管活性肠肽

Abstract:

To explore the effect of substances P(SP) and vasoactive intestinal peptide in the tongue base tissue on retrolingual obstruction in patients with obstructive sleep apneahypopnea syndrome (OSAHS). MethodsExpressions of SP and vasoactive intestinal peptide in tongue base tissues of 49 patients with OSAHS were analyzed by immunohistochemical staining. ResultsThere were a lot of expressions of SP and vasoactive intestinal peptide in the tongue base tissues of OSAHS patients, which mainly lay in the submucosa tissue and small blood vessels around the gland acini and ducts. The positive expression rate of SP was 80.6% (25/31) and 33.3% (6/18) in those with hypertrophic tongue base and those without hypertrophic tongue base respectively (χ2=10.97, P=0.000?9). The positive expression rate of vasoactive intestinal peptide was 90.3% (28/31) and 55.6% (10/18) in the above mentioned two groups respectively (χ2=12.296?9, P=0.000?5). ConclusionsThere are a lot of expressions of SP and vasoactive intestinal peptide in the tongue base tissues of OSAHS patients, which causes local tissue swelling and participates in neurogenic inflammation, and then causes tongue base hypertrophy and collapse.

Key words: Sleep apnea syndrome, Obstructive; Tongue base tissues; Substances P; Vasoactive intestinal peptide

中图分类号:

R563.8

王岩1，李延忠1，王卫之2. P物质、血管活性肠肽在OSAHS患者舌根组织中的表达及意义[J]. 山东大学学报(医学版), 2009, 47(12): 105-107.

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