HPLC法测定降糖宁胶囊中格列本脲含量的不确定度分析

山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (11): 124-127.

HPLC法测定降糖宁胶囊中格列本脲含量的不确定度分析

凌霄¹，解斐²，吴敬德³

1. 山东省药品检验所, 济南 250101; 2. 山东大学威海分校海洋学院, 山东威海 264209;
3. 山东大学药学院有机化学教研室, 济南 250012

收稿日期:2009-03-09 发布日期:2009-11-16
通讯作者: 吴敬德(1970- ),副教授,主要从事药物合成的研究.Email:wujingde70@sdu.edu.cn
作者简介:凌霄(1970- ),主管药师,主要从事药物分析的研究。

Uncertainty of the content of Glibenclamide in Chinese Traditional Medicine determined by HPLC

LING Xiao ¹ , XIE Fei ² , WU Jingde ³

1. Shandong Provincial Institute for Drug Control, Jinan 250101, China;
2. Marine College, Shandong University at Weihai, Weihai 264209, Shandong, China;
3. Department of Organic Chemistry,School of Pharmacy, Shandong University, Jinan 250012, China

Received:2009-03-09 Published:2009-11-16

摘要/Abstract

摘要：

目的建立高效液相色谱法(HPLC)测定掺入降糖宁中的格列苯脲含量的不确定度评定方法。方法建立数学模型,对含量测定过程中各影响因素进行分析评估。结果通过不确定度来源的识别及量化分析,计算各变量的不确定度和合成不确定度,得出测定结果的扩展不确定度。结论该评定方法适用于HPLC法测定中药中非法掺入的格列苯脲含量的不确定度评定。
关键词:高效液相色谱法;格列苯脲;不确定度

关键词: 高效液相色谱法;格列苯脲;不确定度

Abstract:

To establish a method for evaluation of uncertainty of determination of glibenclamide illegally added in Jiangtangning by HPLC. MethodsThe uncertainty was evaluated by a established mathematical model and various factors affecting sample detection were analyzed. ResultsUncertainty of each componet was calculated and their combined uncertainty was then finally obtained by synthesizing the uncertainties of various component variables. ConclusionThis method is appropriate to be used in uncertainty evaluation for determination of declofenac sodium in Chinese traditional medicine by HPLC.

Key words: High performance liquid chromatography; Glibenclamide; Uncertainty

中图分类号:

R73941

凌霄1，解斐2，吴敬德3. HPLC法测定降糖宁胶囊中格列本脲含量的不确定度分析[J]. 山东大学学报(医学版), 2009, 47(11): 124-127.

参考文献

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed