关键词: 心肌肌钙蛋白T；心肌梗死；心肌梗死定量；肌酸激酶MBmass；肌酸激酶MB活性

Abstract:

To investigate the effect of incidence of acute myocardial infarction (AMI) associated with diabetes mellitus or hypertension on myocardial infarction size.  Methods62 patients with AMI hospitalized from June 2006 to June 2008 were divided into three groups according to complications: group A contained 18 patients who had AMI with diabetes mellitus, group B contained 21 patients who had AMI with hypertension, and group C contained 23 patients who had AMI without diabetes mellitus or hypertension. Then cTnT, CKMBmass and CKMBact were kinetically measured in these patients. Results①Abnormal changes of serum cTnT, CKMBmass, and CKMBact levels appeared at 3.9, 2.9, 3.0?h respectively in group A, while at 3.5, 1.6, 2.3?h in group B, and at 2.8, 1.3, 1.7?h respectively in group C. ② The maximal values of cTnT, CKMBmass and CKMBact appeared at 38.9, 28.5, 32.4?h in group A, at 35.4, 26.7, 29.5?h in group B, and at 30.5, 18.2, 20.7?h in group C. ③ cTnT, CKMBmass and CKMBact returned to the baseline levels at 78.5, 72.6, 63.2?h in group A, at 58.7, 52.4, 41.7?h in group B, and at 62.5, 58.6, 52.5?h in group C. ④ Quantity of injured myocardial in group A was 45.2 cTnTg, 42.5 CKMBmassg, and 45.7 CKMBactg; in group B was 40.8 cTnTg, 37.4 CKMBmassg, and 39.2 CKMBactg; ingroup C was 31.4 cTnTg, 28.7 CKMBmassg, and 31.6 CKMBactg. ConclusionsAMI patients complicated with diabetes mellitus and hypertension have highly critical conditions, which maybe attribute to an increased myocardial infarct size.

Key words: Cardiac troponin T； Myocardial infarction； Infarct quantitative analysis； Creatine KinaseMB mass； Creatine KinaseMB act