人类群体遗传空间结构分析的典型趋势面模型

山东大学学报(医学版) ›› 2009, Vol. 47 ›› Issue (8): 128-132.

人类群体遗传空间结构分析的典型趋势面模型

张茜,薛付忠

山东大学公共卫生学院流行病与卫生统计学研究所, 济南 250012

收稿日期:2009-04-22 发布日期:2009-08-16
通讯作者: 薛付忠(1964- ),男,医学博士,副教授,主要从事空间流行病学与空间遗传学理论与统计分析方法及其应用研究。Email: xuefzh@sdu.edu.cn
作者简介:张茜(1985- ),女,预防医学本科在读,信息与计算科学双学位,主要从事空间流行病学理论与统计分析方法及其应用研究。
基金资助:
国家“863”项目资助课题(2007AA02Z312)。

Spatial canonical trend surface models of human population genetic structure analysis

ZHANG Qian, XUE Fuzhong

Institute of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan 250012, China

Received:2009-04-22 Published:2009-08-16

摘要/Abstract

摘要：

目的建立人类群体遗传空间结构分析的典型趋势面模型。方法以mtDNA系统的遗传空间结构组分分析为实例,结合典型相关分析与趋势面分析方法,应用arcGIS 93和SAS 913软件建立基于群体遗传空间结构的典型趋势面模型。结果mtDNA系统遗传结构的分析实例表明，此模型可定量地将人类群体遗传空间结构剖分为遗传梯度趋势和地理距离隔离,分离具有群体遗传学意义的遗传结构区域。结论人类群体遗传空间结构分析的典型趋势面模型,可以定量揭示和分离人类群体遗传空间结构组分特征,为阐明群体遗传学和人类学问题提供依据。

关键词: 人类群体遗传空间结构;空间遗传学;典型趋势面;趋势面分析

Abstract:

To establish a spatial canonical trend surface model of human population genetic structure analysis. MethodsUsing canonical correlation analysis in combination with trend surface analysis,and arcGIS 93 and SAS 913, the spatial canonical trend surface analysis models were set up based on the example of mtDNA system spatial genetic structure analysis. ResultsWith the example of the mtDNA system, the spatial canonical trend surface analysis model quantitatively divided the spatial genetic structure of human population into the genetic and the geographical, and also separated the genetic trend surface which had population genetics importance. ConclusionSpatial canonical trend surface analysis models of human population genetic structure can quantitatively reveal and separate the spatial structure and composition of population genetic structure, and provide statistical proofs of population genetics and anthropology.

Key words: Human population spatial genetic structure; Spatial heterogeneity; Canonical trend surface; Trend surface analysis

中图分类号:

R1951

. 人类群体遗传空间结构分析的典型趋势面模型[J]. 山东大学学报(医学版), 2009, 47(8): 128-132.

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