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山东大学学报（医学版）

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急性脑梗死患者阿司匹林抵抗与血小板miR126的相关性

王建丽1，张涌2，朱媛媛3，李彬2，管益超1，耿婷4   

  1. 1. 山东大学医学院，山东 济南250012；2.山东大学附属济南市中心医院保健科，山东 济南 250013；
    3. 山东大学齐鲁医院血液病研究室，山东 济南 250012； 4.潍坊医学院，山东 潍坊 261053
  • 收稿日期:2013-11-27 出版日期:2014-05-10 发布日期:2014-05-10
  • 通讯作者: 张涌 E-mail：yongzhang-yz@126.com
  • 基金资助:
    国家自然科学基金（81070919）

A correlation study between aspirin resistance and  platelet miR126 in acute cerebral infarction patients

WANG Jianli1, ZHANG Yong2, ZHU Yuanyuan3, LI Bin2， GUAN Yichao1， GENG Ting4   

  1. 1. School of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Department of Geriatrics, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China;
    3. Department of Hematology Laboratory, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;
    4. Weifang Medical College, Weifang 261053, Shandong, China
  • Received:2013-11-27 Online:2014-05-10 Published:2014-05-10

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摘要： 目的  探讨急性脑梗死患者阿司匹林抵抗（AR）与血小板miR126的相关性。方法  选择51例急性脑血栓形成患者作为病例组，60例无脑梗、心梗的健康人作为对照组。通过血小板聚集实验区分AR和非阿司匹林抵抗（NAR），采用RT-PCR检测血小板miR126水平。结果  病例组血小板miR126水平低于对照组（P＜0.05）；对照组中AR的miR126水平明显高于NAR（P＜0.05）。结论  急性脑梗死患者血小板miR126水平低于健康人，但与AR无相关性；血小板miR126水平降低在一定程度上提示急性脑梗死的发生。

关键词: 阿司匹林抵抗, 急性脑梗死, miR126, 非阿司匹林抵抗

Abstract: Objective  To investigate the correlation between platelet miR126 and aspirin resistance (AR) in acute cerebral infarction patients. Methods  Fifty-one patients with acute cerebral thrombosis were treated as the case group, and sixty volunteers of non-cerebral infarction and non-myocardial infarction were treated as the control group. The AR and non-aspirin resistance (NAR) were distinguished by the platelet aggregation experiments, and the levels of miR126 were detected by RT-PCR assay. Results  miR126 levels in the case group were less than those in the control group (P<0.05). miR126 levels of AR were significantly higher than those of NAR in the control group (P<0.05). Conclusion  Platelet miR126 levels of acute cerebral infarction patients are lower than the volunteers, however, it is not related to AR of patients. Lower level of platelet miR126 prompts acute cerebral infarction to some extent.

Key words: Non-aspirin resistance, Acute cerebral infarction, miR126, Aspirin resistance

中图分类号: 

  • R741.02
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