趋化因子受体3及血管生成拟态在结肠癌肝转移中的作用

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (8): 96-99.

趋化因子受体3及血管生成拟态在结肠癌肝转移中的作用

任鹏1，郝青2，王杰书3，李洪林3，李波3，王峰3

1.南方医科大学南方医院普外科，广州 510515； 2.滨州市中心医院病理科，山东滨州 251700；
3.滨州市中心医院普外科，山东滨州 251700

收稿日期:2012-03-28 出版日期:2012-08-10 发布日期:2012-08-10
作者简介:任鹏(1964- )，男，博士研究生，教授，硕士生导师，主要从事胃肠道恶性肿瘤研究。

Roles of CXC chemokine receptor 3 and vasculogenic mimicry in
hepatic metastasis of colonic carcinoma

REN Peng1， HAO Qing2， WANG Jie-shu3， LI Hong-lin3， LI Bo3， WANG Feng3

1. Department of General Surgery， Nanfang Hospital， Southern Medical University， Guangzhou 510515， China；
2. Department of Pathology； 3. Department of General Surgery, Binzhou Central Hospital， Binzhou 251700， Shandong， China

Received:2012-03-28 Online:2012-08-10 Published:2012-08-10

摘要/Abstract

摘要：

目的探讨趋化因子受体3(CXCR3)及血管生成拟态(VM)在结肠癌肝转移中的表达及其与临床指标的关系。方法免疫组织化学染色检测40例结肠癌肝转移手术标本(A组)和30例结肠癌无肝转移手术标本(B组)CXCR3的表达，过碘酸雪夫氏(PAS)染色检测结肠癌组织中VM的表达，分析CXCR3和VM与临床指标的相关性。结果 A组结肠癌组织中CXCR3阳性表达率77.5% ，VM阳性表达率72.5%，肝转移瘤中CXCR3阳性表达率75.0%；B组结肠癌组织CXCR3阳性表达率43.3%，VM阳性表达率20.0%，两组间差异有统计学意义。相关性分析表明，CXCR3的表达与结肠癌分化程度、淋巴结转移、肝转移呈正相关，CXCR3与VM阳性表达也呈正相关(P＜0.05)。结论 CXCR3和VM 在结肠癌肝转移组的结肠癌组织中高表达，CXCR3和VM 的表达与结肠癌的转移及分化程度有关。

关键词: 趋化因子受体3；血管生成拟态；结肠癌；肝转移；免疫组织化学；PAS染色

Abstract:

Objective To investigate the expressions of CXC chemokine receptor 3 (CXCR3) and vasculogenic mimicry (VM) in hepatic metastasis of colonic carcinoma and their relationships with clinical parameters. Methods The expression of CXCR3 was detected by immunohistochemical staining in surgical specimens of colonic carcinoma with (group A, 40 cases) or without (group B, 30 cases) hepatic metastasis. The expression of VM was detected by Periodic acid-Schiff (PAS) staining in colonic carcinoma. Relationships between the above two indicators and clinical parameters were analyzed. Results Positive expression rates of CXCR3 and VM in the colonic carcinoma of group A were 77.5% and 72.5% respectively, while the positive rate of CXCR3 was 75.0% in the hepatic metastases of this group. Positive expression rates of CXCR3 and VM in the colonic carcinoma of group B were 43.3% and 20.0% respectively. There were significant differences between the two groups. Expression of CXCR3 in colonic carcinoma was positively related to histologic differentiation, lymph node metastasis and hepatic metastasis. Meanwhile, the expression of CXCR3 was also positively correlated with that of VM (P<0.05). Conclusion CXCR3 and VM are highly expressed in colonic carcinoma tissue of group A. Expressions of CXCR3 and VM are correlated with histologic differentiation and the metastasis of colonic carcinoma.

Key words: CXC chemokine receptor 3； Vasculogenic mimicry； Colonic carcinoma； Hepatic metastasis；Immunohistochemistry； PAS staining

中图分类号:

R735.3

任鹏1，郝青2，王杰书3，李洪林3，李波3，王峰3. 趋化因子受体3及血管生成拟态在结肠癌肝转移中的作用[J]. 山东大学学报(医学版), 2012, 50(8): 96-99.

REN Peng1， HAO Qing2， WANG Jie-shu3， LI Hong-lin3， LI Bo3， WANG Feng3. Roles of CXC chemokine receptor 3 and vasculogenic mimicry in
hepatic metastasis of colonic carcinoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(8): 96-99.

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