梗阻性肾病血清中Ⅲ型胶原水平与肾功能改变的相关性研究

山东大学学报(医学版) ›› 2012, Vol. 50 ›› Issue (3): 62-65.

梗阻性肾病血清中Ⅲ型胶原水平与肾功能改变的相关性研究

马敏1,张亮2,邵光峰1,张磊1，刘玉强1

山东大学第二医院 1.泌尿外科； 2.急诊科，济南 250033

收稿日期:2011-11-28 出版日期:2012-03-10 发布日期:2012-03-10
通讯作者: 刘玉强(1958- )，男，教授，主要从事泌尿外科疾病的研究。 E-mail：lyq-sdql@163.com
作者简介:马敏(1982- )，男，硕士研究生，主要从事泌尿外科疾病的研究。

Relationship between collagen type Ⅲ in serum and
renal function in obstructive nephropathy

MA Min1, ZHANG Liang2, SHAO Guang-feng1, ZHANG Lei1, LIU Yu-qiang1

1. Department of Urology; 2. Department of Emergency, The Second Hospital of
Shandong University, Jinan 250033, China

Received:2011-11-28 Online:2012-03-10 Published:2012-03-10

摘要/Abstract

摘要：

目的探讨梗阻性肾病患者血清中Ⅲ型前胶原(PCⅢ)及Ⅲ型前胶原氨基末端肽(PⅢNP)浓度的变化与肾功能受损程度及可复性的关系。方法收集本院泌尿外科单侧肾积水患者30例，分为3组，轻度肾积水组、中度肾积水组、重度肾积水组各10例，另外取10例健康者作为对照组；采用放射免疫法测定各组血清中PCⅢ及PⅢNP的含量；用99mTc-DTPA肾动态显像法测定各积水组治疗前后的肾小球滤过率(GFR)；对血清中PCⅢ及PⅢNP含量与治疗前后GFR进行相关性研究。结果 ①3组肾积水患者血清中PCⅢ及PⅢNP值整体上较对照组均升高，且随积水程度加重血清中PCⅢ及PⅢNP值逐渐升高，各积水组与对照组、以及各积水组两两间比较差异有统计学意义(P<0.05)；②肾积水患者血清PCⅢ及PⅢNP浓度与术前患侧GFR呈负相关(r=-0.819，P<0.01)；③轻度及中度积水组治疗后患侧GFR明显升高(P<0.05)，重度积水组治疗后患侧GFR升高不明显(P>0.05)。结论肾积水患者血清中PCⅢ及PⅢNP值随积水程度加重逐渐升高；肾积水血清中PCⅢ及PⅢNP值与患侧GFR呈负相关；推测在排除肾外脏器纤维化的前提下，血清PCⅢ及PⅢNP对评价肾积水肾功能变化具有一定指导意义。

关键词: 肾积水；肾纤维化；Ⅲ型胶原；肾小球滤过率

Abstract:

Objective To explore the relationship between the concentrations of type Ⅲ procollagen(PCⅢ) and aminoterminal propeptide of type Ⅲ procollagen(PⅢNP)in serum of obstructive nephropathy and the damage and recovery of renal function. Methods Thirty patients suffering from unilateral hydronephrosis were divided into three groups: the mild hydronephrosis group(10 cases) and the moderate hydronephrosis group (10 cases) and severe hydronephrosis group (10 cases) . 10 healthy people were chosen as the control group. PCⅢ and PⅢNP concentrations in serum were measured by radioimmunoassay (RIA). Preoperative and postoperative Glomerular Filtration Rates (GFRs)were measured by nephrodynamic imaging and then the relationship between PCⅢ and PⅢNP concentrations in serum and GFRs was studied. Results ①PCⅢ and PⅢNP concentrations in serum of the three hydronephrosis groups were all higher than the control group, and PCⅢ and PⅢNP concentrations in serum increased gradually with the increasing degree of the hydronephrosis. The differences between the hydronephrosis group and the control group and among the hydronephrosis groups were significant(P<0.05).②There was a negative correlation between PCⅢ and PⅢNP concentrations in serum of the three hydronephrosis groups and preoperative GFRs(r=-0.819，P<0.01).③The postoperative GFRs were higher than the preoperative GFRs of the mild and moderate hydronephrosis groups(P<0.05) and the postoperative GFRs of the severe hydronephrosis group did not significantly recover(P>0.05). Conclusion PCⅢ and PⅢNP concentrations in serum of the hydronephrosis groups gradually increased with the increasing degree of the hydronephrosis. There was a negative correlation between PCⅢ and PⅢNP concentrations in serum of the three hydronephrosis groups and preoperative GFRs. So we presumed that the PCⅢ and PⅢNP concentrations in serum could be used to indicate the changes of renal function in hydronephrosis, on condition that the possibility of other organs′ fibrosis was ruled out.

Key words: Hydronephrosis; Renal fibrosis; Collagen type Ⅲ; Glomerular filtration rate

中图分类号:

R692.2

马敏1,张亮2,邵光峰1,张磊1，刘玉强1. 梗阻性肾病血清中Ⅲ型胶原水平与肾功能改变的相关性研究[J]. 山东大学学报(医学版), 2012, 50(3): 62-65.

MA Min1, ZHANG Liang2, SHAO Guang-feng1, ZHANG Lei1, LIU Yu-qiang1. Relationship between collagen type Ⅲ in serum and
renal function in obstructive nephropathy[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2012, 50(3): 62-65.

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