关键词: 高血压；代谢综合征；微量白蛋白尿；高分子量脂联素

Abstract:

Objective  To compare the differences of microalbuminuria(MAU) and serum high molecular weight-adiponectin(HMW-ADP) between essential hypertensive patients and hypertensive patients with metabolic syndrome(MS)，and to explore the association of MAU and HMW-ADP in hypertensive patients with MS. Methods  68 essential hypertensive patients were enrolled and divided into two groups by the definition of MS: the  MS and hypertension group (n=33) and the pure  hypertension group (n=35). The urine albumin-to-creatinine ratio（ACR） was measured by radioimmunoassay. Serum HMW-ADP was determined by sandwich ELISA. Results  The MAU level was higher and the level of serum HMW-ADP was lower in the MS and hypertension group than in the hypertension group（P＜0.01）． Pearson correlation analysis showed that HMW-ADP was not correlated with ACR（P＞0.05）. Binary logistic regression showed that fasting plasma glucose, high density lipoprotein cholesterol, triglyceride, low density lipoprotein cholesterol, ACR and HMW-ADP were associated with the development of MS in hypertensive patients(P＜0.05-0.01). Conclusions  MS aggravates kidney damage in hypertensive patients. HMW-ADP is not correlated with ACR. Increase of ACR and decrease of HMW-ADP promote development of MS in patients with hypertension．

Key words: Essential hypertension; Metabolic syndrome; Microalbuminuria; High molecular weight-adiponectin