山东汉族人群DBP基因多态性与多发性硬化的相关性

山东大学学报(医学版) ›› 2010, Vol. 48 ›› Issue (4): 67-.

山东汉族人群DBP基因多态性与多发性硬化的相关性

李晓红1,2，李芸1，王班琴1，刘师莲1

1. 山东大学医学院生物化学与分子生物学研究所，济南 250012；
2. 山东省济南卫生学校生化教研室，济南 250023

收稿日期:2009-11-30 出版日期:2010-04-16 发布日期:2010-04-16
通讯作者: 刘师莲（1957- ），女，教授，主要从事神经蛋白质组学的研究。 Email:liushilian@sdu.edu.cn
作者简介:李晓红（1975- ），女，硕士研究生，主要从事分子生物学的研究 Email:lixhyy2008@126.com

Association of DBP gene polymorphism and risk of multiple sclerosis in Han people of Shandong Province

LI Xiaohong1,2, LI Yun1, WANG Banqin1, LIU Shilian1

1. Institute of Biochemistry and Molecular Biology, School of Medicine, Shandong University, Jinan 250012, China;
2. Jinan Health School of Shandong Province, Jinan 250023, China

Received:2009-11-30 Online:2010-04-16 Published:2010-04-16

摘要/Abstract

摘要：

目的初步探讨山东汉族人群中DBP基因416和420位点基因多态性与多发性硬化(MS)疾病发生的关系。方法经临床诊断为MS患者46例为MS患病组，同期健康体检者43例为对照组，检测其DBP基因416位点（HaeⅢ酶切位点）和420位点（StyⅠ酶切位点）基因多态性，并进行统计学分析。结果 MS患病组和对照组比较，DBP基因416位点和420位点基因型频率、等位基因频率和表现型频率分布差异均不显著。结论山东汉族人群中DBP基因416位点和420位点基因多态性与MS疾病发生无显著相关性。

关键词: 多发性硬化; 维生素D结合蛋白质; 多态性,单核苷酸

Abstract:

Objective To investigate the association of two polymorphisms (codon 416 and codon 420) in the DBP gene and multiple sclerosis(MS) in Han people of Shandong province. Methods The cas-control study involving 46 patients with clinically determined multiple sclerosis (MS) and 43 healthy controls. DBP gene polymorphisms at codon 416 (digested by Hae Ⅲ) and 420 (digested by styⅠ) were determined by polymerase chain reaction with the following restriction analysis of ampliaticfions. Result There was no significant distinctions of genotypes frequencies and allele frequencies between control group and the patients with multiple sclerosis. Conclusion DBP gene polymorphism is not associated with risk of development of multiple sclerosis in Han people of Shandong Province.

Key words: Multiple sclerosis; Vitamin Dbinding protein; Polymorphism, single nucleotide

中图分类号:

R744.5

李晓红1,2，李芸1，王班琴1，刘师莲1. 山东汉族人群DBP基因多态性与多发性硬化的相关性[J]. 山东大学学报(医学版), 2010, 48(4): 67-.

LI Xiaohong1,2, LI Yun1, WANG Banqin1, LIU Shilian1. Association of DBP gene polymorphism and risk of multiple sclerosis in Han people of Shandong Province[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2010, 48(4): 67-.

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