PDCD4和Ki67蛋白在不同期蕈样肉芽肿中的表达

山东大学学报(医学版)

PDCD4和Ki67蛋白在不同期蕈样肉芽肿中的表达

于淑萍¹，马春虎²，王玉坤¹

（1. 山东大学齐鲁医院皮肤科，济南 250012；
2. 承德医学院药理教研室, 河北承德 067000）

收稿日期:1900-01-01 修回日期:1900-01-01 发布日期:2009-04-16
通讯作者: 王玉坤

Expressions of programmed cell death 4 and
Ki67 in granuloma fungoides

YU Shuping¹， MA Chunhu²， WANG Yukun¹

(1. Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, China；
2. Department of Pharmacology，Chengde Medical College, Chengde 067000, Hebei, China)

Received:1900-01-01 Revised:1900-01-01 Published:2009-04-16
Contact: WANG Yukun

摘要/Abstract

摘要： 目的探讨程序性细胞凋亡因子4（PDCD4）和Ki67蛋白在不同期蕈样肉芽肿（MF）皮损中的表达。方法选择27例MF病变皮肤及5例正常皮肤组织蜡块,分为:红斑/斑块期MF(n＝21)、肿瘤期MF（n＝6）和正常对照组（n＝5）,应用免疫组织化学Envison两步法分别检测3组标本表皮及真皮中PDCD4及Ki67的表达。结果①红斑/斑块期MF皮损表皮PDCD4＋细胞与正常对照组比较差异无统计学意义（P>0.05）,真皮PDCD4＋细胞明显少于正常对照组（P<0.05）；肿瘤期MF皮损表皮及真皮PDCD4＋细胞均少于正常对照组和红斑/斑块期MF（P<0.05）；②两组MF表皮Ki67＋细胞的数量与正常对照组比较差异无统计学意义（P>0.05），红斑/斑块期MF及肿瘤期MF皮损真皮Ki67＋细胞均多于正常对照组（P<0.05）；肿瘤期MF皮损真皮Ki67＋细胞高于红斑/斑块期MF皮损（P<0.05）；③各期MF的表皮及真皮中PDCD4和Ki67的表达无相关性（P>0.05）。结论PDCD4的表达从MF的红斑/斑块期到肿瘤期逐渐减低，真皮中Ki67的表达逐渐增强，MF的发生与发展可能与PDCD4表达降低或缺失有关。

关键词: 程序性细胞凋亡因子, 蕈样肉芽肿, Ki67蛋白

Abstract: To explore the expressions of Programmed Cell Dead Factor4 and Ki67 in the skin infiltrates of patients with granuloma fungoides(MF) in different stages. MethodsParaffin sections were divided into three groups: the patch/plaque stage group(n=21), the tumor stage group(n=6), and the control group(n=5).　The immunohistochemical Envision method was used to determine expressions of PDCD4 and Ki67 per section． Results①There was no significant difference in the number of PDCD4+ cells in the epidermis between the patch/plaque stage and control groups (P>0.05), while the number of PDCD4+ cells in the dermis was significantly lower than that in the control group(P<0.05). The number of PDCD4+ cells in both the epidermis and dermis of the tumor stage group was significantly lower than in the patch/plaque stage and control groups (P<0.05). ② There was no significant difference in the number of Ki67+ cells in the epidermis in the three groups(P>0.05).　The number of Ki67+ cells in dermis of both the patch/plaque stage and the tumor stage groups were significantly higher than the control group (P<0.05), while the number of Ki67+ cells of the tumor stage group was significantly higher than that of the patch/plaque stage group (P<0.05). ③There was no correlation between expression of PDCD4 and that of Ki67 in the epidermis or dermis (P>0.05). ConclusionsDecreased PDCD4 expression in both the epidermis and dermis and increased Ki67 expression in the dermis from patch/plaque stage to tumor stage MF suggest that the incidence and development of MF may be related to the decrease or deficiency of PDCD4 expression.

Key words: Programmed cell death 4, Granuloma fungoides, Ki67

中图分类号:

R246.7

于淑萍1 ，马春虎2 ，王玉坤1
. PDCD4和Ki67蛋白在不同期蕈样肉芽肿中的表达[J]. 山东大学学报(医学版), 2009, 47(04): 104-104.

YU Shuping¹， MA Chunhu²， WANG Yukun¹
. Expressions of programmed cell death 4 and
Ki67 in granuloma fungoides[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2009, 47(04): 104-104.

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