p53在单纯肠化、不典型肠化与胃癌中的表达

山东大学学报(医学版)

p53在单纯肠化、不典型肠化与胃癌中的表达

赵著梅,张建平,杨京彦,刘文君,王妍,周志强

山东大学齐鲁医院病理科，济南 250012

收稿日期:2007-11-05 修回日期:1900-01-01 出版日期:2008-02-16 发布日期:2008-02-16
通讯作者: 张建平

Expressions and significance of p53 proteins in simple intestinal metaplasia, atypical intestinal

ZHAO Zhu-mei, ZHANG Jian-ping, YANG Jing-yan, LIU Wen-jun, WANG Yan, ZHOU Zhi-qiang

Department of Pathology, Qilu Hospital of Shandong University, Jinan 250012, China

Received:2007-11-05 Revised:1900-01-01 Online:2008-02-16 Published:2008-02-16
Contact: ZHANG Jian-ping

摘要/Abstract

摘要： 目的探讨p53在单纯肠化、不典型肠化与胃癌中的表达。方法观察肠化的病理形态特点,将肠化分为单纯肠化和不典型肠化。应用免疫组织化学Envison法检测22例单纯肠化、30例不典型肠化和40例胃癌中p53的表达,分析其与单纯肠化、不典型肠化及胃癌的关系。结果p53在单纯肠化、不典型肠化及胃癌中的阳性率分别为13.6％、40.0％、55.0％,其表达逐渐增多。其中单纯肠化与胃癌比较差异有统计学意义(P＜0.05),不典型肠化与胃癌比较差异无统计学意义(P＞0.05)。结论p53蛋白异常表达参与了胃粘膜肠化及癌变的过程,提示不典型肠化与胃癌关系密切。

Abstract: To study the expressions of p53 in simple intestinal metaplasia(SIM), atypical intestinal metaplasia(AIM)and gastric adenocarcinoma. MethodsThe immunohistochemical EnVision method was used to determine the expressions of p53 in simple intestinal metaplasia(SIM), atypical intestinal metaplasia(AIM)and gastric adenocarcinoma. ResultsThe positive rates of p53 in SIM, AIM and gastric adenocarcinoma was 13.6％, 40.0％ and 55.0％. The expression of p53 in AIM was significantly higher than that in SIM. There was no significant differences between AIM and gastric adenocarcinoma. Conclusionp53 may play an important role in intestinal meteplasia and gastric carcinoma.

Key words: Simple intestinal metaplasia, Atypical intestinal metaplasia, Protein p53

中图分类号:

R365

赵著梅,张建平,杨京彦,刘文君,王妍,周志强. p53在单纯肠化、不典型肠化与胃癌中的表达[J]. 山东大学学报(医学版), 2008, 46(2): 178-180.

ZHAO Zhu-mei,ZHANG Jian-ping,YANG Jing-yan,LIU Wen-jun,WANG Yan,ZHOU Zhi-qiang. Expressions and significance of p53 proteins in simple intestinal metaplasia, atypical intestinal[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(2): 178-180.

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