八氟丙烷人血白蛋白微球注射液对改善左心室内膜边界显影作用的研究

山东大学学报(医学版)

八氟丙烷人血白蛋白微球注射液对改善左心室内膜边界显影作用的研究

王志蕴，陈良，张梅，蒋桂花，姚桂华，卜培莉，季晓平，张运

教育部和卫生部心血管重构和功能重点实验室山东大学齐鲁医院心内科，济南 250012

收稿日期:2007-02-16 修回日期:1900-01-01 出版日期:2008-01-16 发布日期:2008-01-16
通讯作者: 张梅

Clinical trial of human albumin microspheres，injectable suspension octfluoropropane formulation for improvement ofendocardial border delineation

WANG Zhi-yun, CHEN Liang, ZHANG Mei, JIANG Gui-hua, YAO Gui-hua,BU Pei-li, JI Xiao-ping, ZHANG Yun

Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese

Received:2007-02-16 Revised:1900-01-01 Online:2008-01-16 Published:2008-01-16
Contact: ZHANG Mei

摘要/Abstract

摘要： 目的应用超声技术观察第2代声学造影剂八氟丙烷人血白蛋白微球注射液对心内膜临床使用的有效性和安全性。方法将45例透声较差、心内膜显示不清的患者，分别静脉注射八氟丙烷人血白蛋白微球注射液0.01mL/Kg进行实时声学造影，评价心内膜缘显影改善情况。结果内膜显影改善率为96.9%，且对心电图、血压、呼吸、心率、血常规、尿常规、肝、肾功能等均无影响。结论八氟丙烷人血白蛋白微球注射液，能够明显地改善心内膜边缘显像。

Abstract: To explore the safety and efficacy of human albumin microspheres，injectable suspension octfluoropropane formulation for left ventricular endocardial border delineation（LVEBD）. MethodsFortyfive patients with suboptimal echocardiography were enrolled in this study. Each patient received 0.01ml/kg human albumin microspheres，injectable suspension octfluoropropane formulation. Twelve segments in apical fourand twochamber views were scored for LVEBD. ResultsLVEBD was significantly improved in 96.9% segments. There were no significant changes of electrocardiogram， heart rates， blood pressure，respiratory，blood routine，urine routine，liver function and kidney function observed after treatments. ConclusionsAlbumin microspheres，injectable suspension octfluoropropane formulation is safe and valuable for LVEBD assessment.

Key words: Human albumin microspheres，injectable suspension octfluoropropane formulation, Echocardiographic contrast, Endocardiol border delineation

中图分类号:

R423

王志蕴,陈良,张梅,蒋桂花,姚桂华,卜培莉,季晓平,张运. 八氟丙烷人血白蛋白微球注射液对改善左心室内膜边界显影作用的研究[J]. 山东大学学报(医学版), 2008, 46(1): 97-99.

WANG Zhi-yun, CHEN Liang, ZHANG Mei,JIANG Gui-hua,YAO Gui-hua,BU Pei-li,JI Xiao-ping,ZHANG Yun. Clinical trial of human albumin microspheres，injectable suspension octfluoropropane formulation for improvement ofendocardial border delineation[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(1): 97-99.

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