山东地区HBeAg阴性慢性乙肝和乙肝肝硬化构成比变迁和病毒基因型分析

山东大学学报(医学版)

山东地区HBeAg阴性慢性乙肝和乙肝肝硬化构成比变迁和病毒基因型分析

刘友德¹，王磊¹，周培静¹，庄辉²

1．山东大学医学院济南市传染病院四科，济南 250021； 2．北京大学医学部微生物学系，北京 100083

收稿日期:2007-07-30 修回日期:1900-01-01 出版日期:2008-01-16 发布日期:2008-01-16
通讯作者: 王磊

Proportional changes of HBeAg negative chronic hepatitis B and liver cirrhosis B and the HBV genotype in Shandong Province

LIU You-de¹，WANG Lei¹，ZHOU Pei-jing¹，ZHUANG Hui²

1. Jinan Hospital of Infectious Disease, School of Medicine, Shandong University, Jinan 250021, China; 2. Department of Microbiology, Peking University Health Science Center

Received:2007-07-30 Revised:1900-01-01 Online:2008-01-16 Published:2008-01-16
Contact: WANG Lei

摘要/Abstract

摘要： 目的了解山东地区HBeAg阴性慢性乙型肝炎（CHB）和乙肝肝硬化（LC-B）构成比变迁及基因型。方法采用回顾性研究方法，分析了1996、2001和2006年1～6月住院的全部CHB和LC-B患者共2?561例。采用特异性引物巢式PCR法，检测了220例山东籍CHB和LC-B患者的基因型。结果HBeAg阴性LC-B比例（50.0％）高于CHB（23.8％），P=0.000。HBeAg阴性LC-B构成比由1996年的46.1％上升至2006年的54.4％，P=0.047。山东地区HBeAg阴性CHB和LC-B的C、B/C基因型分别为94.7％、5.3％和90.0%、10.0%，与HBeAg阳性患者无差异；未见B和其他基因型。结论山东地区住院患者中，CHB仍以HBeAg阳性为主；近年来，LC-B中HBeAg阴性患者超过50％。HBeAg阴性和阳性患者，均以C基因型占绝对优势；在HBeAg阴性患者中，未见B基因型。

Abstract: To investigate the proportional changes of HBeAg negative chronic hepatitis B(CHB) and liver cirrhosis of hepatitis B (LC-B) and the HBV genotype in Shandong Province. MethodsThe clinical data of 2?561 hospitalized cases of CHB and LC-B from 1996, 2001 and 2006 were retrospectively analyzed. The HBV genotypes were determined in 220 patients with CHB or LC-B by using the nested polymerase chain reaction based on genotype specific primers. ResultsThe proportion of HBeAg-negative LC-B(50.0%) was higher than that of CHB(23.8%), P＝0.000. It rose from 46.1% in 1996 to 54.4% in 2006, P＝0.047. The percentages of genotype C and B/C mixed genotypes in the HBeAg negative CHB and LC-B groups were 94.7%, 5.3% and 90.0% 10.0% respectively, which were not statistically different from the percentage in the HBeAg positive group. No genotype B or other genotypes were found. ConclusionsIn Shandong Province, HBeA positive is still the predominant form of hospitalized CHB, the proportion of HBeAgnegative LCB has been recently more than 50%. Genotype C is the predominant genotype in both HBeAg negative and positive patients. No genotype B is found in HBeAg negative patients.

Key words: Hepatitis B, chronic, Liver cirrhosis hepatitis B, Hepatitis B, E antigen, Hepatitis B virus, Genotype

中图分类号:

R512.6+2

刘友德,王磊,周培静,庄辉 . 山东地区HBeAg阴性慢性乙肝和乙肝肝硬化构成比变迁和病毒基因型分析[J]. 山东大学学报(医学版), 2008, 46(1): 94-96.

LIU You-de,WANG Lei,ZHOU Pei-jing,ZHUANG Hui. Proportional changes of HBeAg negative chronic hepatitis B and liver cirrhosis B and the HBV genotype in Shandong Province[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2008, 46(1): 94-96.

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