血清TPA、 sVCAM-1与子痫前期发病关系的初步探讨

山东大学学报(医学版)

血清TPA、 sVCAM-1与子痫前期发病关系的初步探讨

张向丽¹,刘凤英²

1. 山东大学齐鲁医院妇产科，山东济南 250012； 2. 济南市第四人民医院妇产科，山东济南 250031

收稿日期:2007-04-20 修回日期:1900-01-01 出版日期:2007-07-24 发布日期:2007-07-24
通讯作者: 张向丽

Correlation between serum TPA and sVCAM-1 and pathogenesis of pre-eclampsia

ZHANG Xiang-li¹,LIU Feng-ying²

Department of Gynecology and Obstetrics, 1. Qilu Hospital of Shandong University， Jinan 250012,Shangdong, China； 2. Jinan Fourth People′s Hospital, Jinan 250031, Shangdong, China

Received:2007-04-20 Revised:1900-01-01 Online:2007-07-24 Published:2007-07-24
Contact: ZHANG Xiang-li

摘要/Abstract

摘要： 目的：探讨组织多肽抗原（tissue polypeptide antigen，TPA）、可溶性血管细胞粘附分子-1（soluble vascular cell adhesion molecule-1,sVCAM-1）与子痫前期发病的关系。方法：采用酶联免疫吸附法（enzyme linked immunosorbent assay，ELISA）测定子痫前期患者（实验组）和正常晚孕妇女（对照组）外周血中TPA、sVCAM-1的浓度，并与子痫前期患者病情及新生儿体重进行相关分析。结果：①轻、重度子痫前期患者外周血TPA浓度均高于正常孕妇，两者比较差异有统计学意义(P重＜0.01，P轻＜0.05)，其中重度患者升高尤为明显；②重度患者外周血sVCAM-1浓度高于轻度患者和正常孕妇，差异有统计学意义(P重＜0.01)；③外周血中TPA浓度和sVCAM-1浓度呈正相关（r=0.419）；④外周血TAP、 sVCAM-1浓度与患者舒张压及24h尿蛋白定量呈正相关(r分别为0.521、0.374)；与新生儿体重呈负相关(r＝-0.614)。结论：随着子痫前期患者病情的加重，母血中TPA、sVCAM1浓度均明显升高，提示胎盘滋养细胞凋亡增多、血管内皮细胞损伤加重。

Abstract: Objective： To explore the correlation of serum tissue polypeptide antigen（TPA）and the soluble vascular cell adhesion molecule-1(sVCAM-1) and pathogenesis of pre-eclampsia. Methods： ELISA was used to determine the serum of TPA and sVCAM-1 in pre-eclamptic(the experimental group) and normotensive pregnant( the control group) women, and the correlation of pre-eclampsia (PE) and neonatal outcomes was analyzed by rank correlation. Results： (1) Concentration of serum TPA in the experimental group was obviously higher than that in the control group (P＜0.05) and it was the highest in patients with serious pre-eclampsia（P＜0.01）. (2) Concentration of serum sVCAM-1 in the severe experimental group was obviously higher than that in the mild experimental and the control groups (P＜0.01). (3) There was a significantly positive correlation between the TPA and the sVCAM-1 in the experimental and control groups. (4) There were a significantly positive correlation between the TPA and sVCAM-1 and the DBP and urine protein in the experimental group, and a significantly negative correlation between the TPA and the sVCAM-1 and the weight of newborns. Conclusion： With the state of the disease worsening, serum TPA and sVCAM-1 is increased, indicating that the apoptosis of the trophoblast cells and the dysfunction of the vascular endothelial cells are aggravated.

Key words: Preeclampsia, Tissue polypeptide antigen, Soluble vascular cell adhesion molecule-1, Neonatal weight

中图分类号:

R714.245

张向丽,刘凤英 . 血清TPA、 sVCAM-1与子痫前期发病关系的初步探讨[J]. 山东大学学报(医学版), 2007, 45(7): 705-707.

ZHANG Xiang-li,LIU Feng-ying. Correlation between serum TPA and sVCAM-1 and pathogenesis of pre-eclampsia[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(7): 705-707.

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