IL-12、IFN-γ与复发性流产的相关性研究

山东大学学报(医学版)

IL-12、IFN-γ与复发性流产的相关性研究

王国华，左常婷,王立俊

山东大学山东省立医院妇产科，山东济南 250021

收稿日期:2006-11-03 修回日期:1900-01-01 出版日期:2007-07-24 发布日期:2007-07-24
通讯作者: 左常婷

Correlation between levels of IL-12 and IFN-γ and recurrent spontaneous abortion

WANG Guo-hua, ZUO Chang-ting, WANG Li-jun

Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan 250021, Shandong, China

Received:2006-11-03 Revised:1900-01-01 Online:2007-07-24 Published:2007-07-24
Contact: ZUO Chang-ting

摘要/Abstract

摘要： 目的：测定复发性流产（RSA）患者血清IL-12、IFN-γ水平，探讨IL-12和IFN-γ与复发性流产发病的关系。方法：采用酶联免疫吸附法检测RSA患者30例(RSA组)，血清IL-12、IFN-γ水平，并以正常早孕妇女25例（NEP组）及健康未孕妇女25例（NNP组）作为两个对照组。结果：RSA患者血清IL-12、IFN-γ水平显著高于正常早孕妇女及正常未孕妇女（P<0.05），且两者水平呈正相关性（r=0.580,P<0.01），正常早孕妇女血清IL-12、IFN-γ水平低于未孕妇女但无统计学意义（P>0.05）。复发性流产患者流产次数与血清IL-12和IFN-γ水平差异无显著性（P>0.05）。结论：IL-12和IFN-γ在复发性流产发生机制中起一定的作用。

Abstract: Objective: To explore the correlation between levels of interleukin-12(IL-12) and interferon-γ(IFN-γ) and recurrent spontaneous abortion (RSA). Methods: Thirty patients with RSA( the RSA group), twenty-five normal early pregnant women (the NEP group) and twentyfive normal non-pregnant women( the NNP group) were enrolled in this study. The serum concentrations of IL-12 and IFN-γwere determined by enzyme-linked immunosorbant assay(ELISA). Results: Levels of IL-12 and IFN-γ were significantly higher in the RSA group than in the other groups(P<0.05) and there was a positive correlation between IL-12 and IFN-γ. Levels of IL-12 and IFN-γ were lower in the NEP group than in the NNP group, but there was no statistical difference(P>0.05). Conclusion： IL-12 and IFN-γ may play an important role in the occurrence of RSA.

Key words: Abortion, habitual, Interleukin-12, Interferon type

中图分类号:

R714.21

王国华,左常婷,王立俊. IL-12、IFN-γ与复发性流产的相关性研究[J]. 山东大学学报(医学版), 2007, 45(7): 702-704.

WANG Guo-hua,ZUO Chang-ting,WANG Li-jun. Correlation between levels of IL-12 and IFN-γ and recurrent spontaneous abortion[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(7): 702-704.

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