脉搏波速度和踝臂指数与心血管危险因素的关系

山东大学学报(医学版)

脉搏波速度和踝臂指数与心血管危险因素的关系

李保应¹，高海青¹，李小利²，马亚兵¹，刘远萍¹，王敏¹

山东大学齐鲁医院 1. 老年病科； 2. 临床药理研究所，山东济南 250012

收稿日期:2006-09-26 修回日期:1900-01-01 出版日期:2007-07-24 发布日期:2007-07-24
通讯作者: 高海青

Correlation between pulse wave velocity and ankle-brachial index and cardiovascular risk factors in elderly patients

LI Bao-ying¹，GAO Hai-qing¹，LI Xiao-li²，MA Ya-bing¹，LIU Yuan-ping¹，WANG Min¹

1. Department of Geriatrics; 2. Institute of Clinical Pharmacology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, China

Received:2006-09-26 Revised:1900-01-01 Online:2007-07-24 Published:2007-07-24
Contact: GAO Hai-qing

摘要/Abstract

摘要： 目的：研究老年患者肱踝脉搏波速度(brachial-ankle pulse wave velocity，baPWV)和踝臂指数(ankle-brachial index, ABI)与心血管危险因素的关系，并探讨baPWV和ABI在老年患者动脉硬化评估中的临床价值。方法：191例老年患者，男123例，女68例，平均年龄（71.73±7.95）岁，采用VP-1000全自动动脉硬化测定仪分别检测患者血压、双侧baPWV和ABI。结果：老年患者中合并大动脉硬化者110例，总发病率为57.6%，与高血压病直接相关(P＜0.05),其OR值为10.569，95%可信区间CI为4.748-23.527,而且与性别、年龄密切相关(P＜0.05)；合并外周血管疾病（peripheral arterial disease，PAD）者36例，发病率为18.8%，并且合并PAD与糖尿病直接有关（P＜0.05），其OR值为4.383，95%可信区间CI为1.974-9.733（P＜0.001）。结论：baPWV和ABI是两个相互独立的无创性、敏感性指标，两者相互结合可以有效地评估老年患者心血管危险因素的危害程度。

Abstract: Objective: To obtain reliable data on the epidemiology, co-morbidities and risk factor profile of large artery arteriosclerosis and peripheral arterial disease (PAD), the clinical significance of brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI) were evaluated as indicators of arteriosclerosis and PAD in aged patients. Methods： One hundred and ninety-one elderly patients (64.4% male, 71.73 years old in mean) were recruited for this study. baPWV and ABI were measured by the VP-1000 automatic arteriosclerosis measurement system. Results: One hundred and ten elderly patients (57.6%) were found to have large artery arteriosclerosis. The risk of large artery arteriosclerosis in elderly patients became higher with an increase of age (OR=1.060, 95% CI=1.010-1.113). Gender (OR=2.494, 95% CI=1.067-5.825) and history of hypertension(OR=10.569, 95% CI=4.74823.527) were independently associated with high baPWV (P＜0. 05). Moreover, 36 elderly patients (18.8%) were found to have PAD. The risk of PAD in elderly patients was related to a history of diabetes mellitus(OR=4.383, 95%CI=1.974-9.733, P＜0.001). Conclusion: BaPWV and ABI measurements are sensitive and independent indicators for evaluating the degree of arteriosclerosis and occlusion in the aged, which can effectively evaluate cardiovascular risk factors in elderly patients.

Key words: Brachial-ankle pulse wave velocity, Anklebrachial index, Arteriosclerosis, Peripheral arterial disease

中图分类号:

R543.5

李保应,高海青,李小利,马亚兵,刘远萍,王敏 . 脉搏波速度和踝臂指数与心血管危险因素的关系[J]. 山东大学学报(医学版), 2007, 45(7): 669-672.

LI Bao-ying,GAO Hai-qing,LI Xiao-li,MA Ya-bing,LIU Yuan-ping,WANG Min. Correlation between pulse wave velocity and ankle-brachial index and cardiovascular risk factors in elderly patients[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(7): 669-672.

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