Abstract: Objective: To investigate the role of COX-2 and VEGF in cell proliferation and angiogenesis of condyloma acuminate（CA）. Methods: Expression of COX-2 and VEGF in 40 cases of CA and 15 normal prepuce skins were determined by immunohistochemistry staining (SP). Results: Positive expression rate of COX-2 and VEGF in CA was 62.5% and 92.5%, respectively ,which was significantly higher than that of the controls （P＜0.05）. Expression of COX-2 and VEGF was strongest throughout the epidermis, but was weak in the basal layer in the control group. Expression of COX-2 was closely related to that of VEGF（P＜0.05）. Expression of COX-2 and VEGF had no correlation with the course of CA(P＞0.05). Conclusions: COX-2 and VEGF simultaneously promote the pathogenesis of CA. It may be an important method for CA by inhibiting the expression of COX-2 and VEGF.

Key words: Condyloma acuminate, Prostaglandin-endoperoxide synthase, Vascular endothelial growth factor, Immunohistochemistry