铝螯合剂对染铝大鼠肾功能及必需元素的影响

山东大学学报(医学版)

铝螯合剂对染铝大鼠肾功能及必需元素的影响

禚金花¹，刘萍¹，林萍²，冯国昌¹，赵慧娟¹，李红彦¹

1. 山东大学公共卫生学院卫生检验研究所，山东济南 250012；2. 山东电子职业技术学院，山东济南 250014

收稿日期:2006-12-18 修回日期:1900-01-01 出版日期:2007-05-24 发布日期:2007-05-24
通讯作者: 刘萍

Effect of aluminum chelating agent on renal function and essential elements of aluminum-induced rats

ZHUO Jin-hua¹，LIU Ping¹，LIN Ping²，FENG Guo-chang¹，ZHAO Hui-juan¹，LI Hong-yan¹

1.Department of Chemistry and Microbacteria Detection, School of Public Health；2.Shandong College of Electronic Technology, Jinan 250014, Shandong, China

Received:2006-12-18 Revised:1900-01-01 Online:2007-05-24 Published:2007-05-24
Contact: LIU Ping

摘要/Abstract

摘要： 目的：探讨铝螯合剂1,2-二甲基-3-羟基-4-吡啶酮(1,2-dimethyl-3-hydroxy-4-pyridone，DHPO)对铝染毒大鼠血清肌酐、尿素氮、尿酸及肾脏中铝、锌、铜、铁、钙、镁等元素的影响。方法：30只雄性Wistar大鼠随机分为6组，阴性对照组、铝染毒组、预防组及低、中、高剂量组，AlCl3染毒3周后分别给予不同剂量的DHPO 1周，测定血清肌酐、尿素氮、尿酸含量及肾脏中铝、锌、铜、铁、钙、镁等元素的含量。结果：铝染毒组尿素氮含量显著高于阴性对照组（P＜0.05），其余各组与阴性对照组相比差异均无统计学意义；各组大鼠血清中肌酐、尿酸含量比较差异均无统计学意义。铝染毒组肾脏中Al含量显著高于阴性对照组（P＜0.01），低、中、高剂量组均显著低于铝染毒组（P＜0.01），且中、高剂量组与阴性对照组相比差异均无统计学意义；铝染毒组、低剂量组大鼠肾脏中铜含量均显著低于阴性对照组（P＜0.01，P＜0.05），而中、高剂量组与阴性对照组相比差异无统计学意义；低、中、高剂量组的大鼠肾脏中锌、铁、钙、镁的含量与阴性对照组相比差异均无统计学意义。结论：DHPO在促排铝的同时，对肾脏中锌、铜、铁、钙、镁含量无影响，且能使受损的肾功能得到恢复。

关键词: 尿酸, 必需元素 , 尿素氮, 螯合剂, 肌酐, 铝

Abstract: Objective: To investigate the effects of 1,2-dimethyl-3-hydroxy-4-pyridone (DHPO) on creatinine(Cr), urea nitrogen(BUN) and uric acid(UA) in serum and on aluminum(Al), zinc(Zn), copper(Cu), iron(Fe), calcium(Ca) and magnesium(Mg) in the kidneys of rats induced by aluminum. Methods: Wistar rats were subjected to aluminum chloride for 3 weeks. Then they were treated with different doses of DHPO. The content of Cr, BUN and UA in the serum was determined, and the concentrations of Al, Zn, Cu, Fe, Ca and Mg in kidney tissues were determined. Results: The BUN content of the Al group was significantly lower than that of the negative control group. The result of UA and Cr contents demonstrated that there was no statistical significance among the groups. The Al level in the kidneys was significantly increased with an intake increase. The aluminum concentration of the three DHPO groups was significantly lower than that of the Al group（P＜0.01）. The aluminum concentration of the moderate and high DHPO groups was not significantly different from that of the negative control group. The Cu concentration of the Al group and the low DHPO group was significantly lower than that of the negative control group, whereas there was no statistical significance between the moderate and high DHPO groups and the negative control group. Compared with the negative control group, the Zn, Fe, Ca, Mg concentrations of the low, moderate and high DHPO groups were not significantly different. Conclusion: DHPO could effectively promote the elimination of Al in kidneys, protect the kidney from Al-induced damage, and has no effect on the excretion of Zn, Cu, Fe, Ca and Mg.

Key words: Aluminum, Chelating agents, Cr, BUN, UA, Essential elements

中图分类号:

R115

禚金花,刘萍,林萍,冯国昌,赵慧娟,李红彦 . 铝螯合剂对染铝大鼠肾功能及必需元素的影响[J]. 山东大学学报(医学版), 2007, 45(5): 459-461.

ZHUO Jin-hua,LIU Ping,LIN Ping,FENG Guo-chang,ZHAO Hui-juan,LI Hong-yan. Effect of aluminum chelating agent on renal function and essential elements of aluminum-induced rats[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(5): 459-461.

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