普通型骨肉瘤中C-kit受体的表达及意义

山东大学学报(医学版)

普通型骨肉瘤中C-kit受体的表达及意义

魏红，李劲松，刘文军

山东大学医学院病理学教研室, 山东济南 250012

收稿日期:2006-12-24 修回日期:1900-01-01 出版日期:2007-03-24 发布日期:2007-03-24
通讯作者: 李劲松

Expression and significance of c-kit in conventional osteosarcoma

WEI Hong， LI Jin-song， LIU Wen-jun

Department of Pathology，School of Medicine, Shandong Univercity， Jinan 250012， Shandong, China

Received:2006-12-24 Revised:1900-01-01 Online:2007-03-24 Published:2007-03-24
Contact: LI Jin-song

摘要/Abstract

摘要： 目的：探讨普通型骨肉瘤组织中C-kit受体(CD117)的表达与骨肉瘤临床病理特点及预后的关系，为临床判断预后及靶向治疗骨肉瘤提供参考依据。方法：采用免疫组织化学方法检测c-kit基因编码产物CD117蛋白在40例普通型骨肉瘤组织中的表达,并结合临床资料分析其与普通型骨肉瘤生物学行为的关系。结果：① C-kit受体在普通型骨肉瘤中表达阳性率为62.5%（25/40）;②C-kit受体高表达者更易局部复发;③C-kit受体高表达组的术后生存时间显著低于C-kit受体低表达组。结论：C-kit受体在普通型骨肉瘤中的表达与骨肉瘤的生物学行为有关，对评价患者的预后及指导临床治疗有一定参考价值。

Abstract: Objective: To investigate the expression of c-kit in conventional osteosarcoma and their relationships with clinicopathological parameters and prognostic value. Methods: The expression of c-kit was determined in 40 patients with conventional osteosarcoma by immunohistochemistry. Their relationship with prognosis was statistically analyzed. Results: (1)The expression rate of c-kit in conventional osteosarcoma was 62.5%．（2）The conventional osteosarcoma with a high expression of c-kit was prone to recur locally. (3)The post-operative survival of patients with highly expressed c-kit was significantly lower than that of patients with lowly expressed c-kit．Conclusion： The expression of c-kit is related to the biological behavior of osteosarcoma in conventional osteosarcoma, and it is valuable in judging the prognosis and therapy for osteosarcoma．

Key words: Osteosarcoma, Prognosis, C-kit, Drug therapy

中图分类号:

R738.1

魏红,李劲松,刘文军. 普通型骨肉瘤中C-kit受体的表达及意义[J]. 山东大学学报(医学版), 2007, 45(3): 243-245.

WEI Hong,LI Jin-song,LIU Wen-jun. Expression and significance of c-kit in conventional osteosarcoma[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(3): 243-245.

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