鼻腔鼻窦内翻性乳头状瘤中MMP-9、PCNA的表达及临床意义

山东大学学报(医学版)

鼻腔鼻窦内翻性乳头状瘤中MMP-9、PCNA的表达及临床意义

刘　鹤¹，邹　雪²，李　敏³，吴晓娟⁴，张立强¹，叶　萍¹，李学忠¹

1.齐鲁医院耳鼻喉科；2. 湖北咸宁学院2004级护理系本科班；3.山东大学公共卫生学院流行病与卫生统计学教研室；4.齐鲁医院病理科

收稿日期:2006-12-21 修回日期:1900-01-01 出版日期:2007-03-24 发布日期:2007-03-24
通讯作者: 李学忠

Expression of MMP-9 and PCNA in sinonasal inverted papilloma and the clinical significance

LIU He¹，ZOU Xue²，LI Min³，WU Xiao-juan⁴，ZHANG Li-qiang¹，YE Ping¹，LI Xue-zhong¹

1.Department of Otorhinolaryngology and Head & Neck Surgery；2. The 2004 Undergraduate Class, Xianning Institute of Hubei Province；3. Institute of Epidemiology and Biostatistics，School of Public Health；4. Department of Pathology

Received:2006-12-21 Revised:1900-01-01 Online:2007-03-24 Published:2007-03-24
Contact: LI Xue-zhong

摘要/Abstract

摘要： 目的：探讨MMP-9、PCNA在鼻内翻性乳头状瘤(SNIP)发病及其复发和恶变中的作用。方法：选取40例SNIP及10例鼻腔鼻窦鳞状细胞癌（SCC）组织蜡块，全部标本分为4组，即良性SNIP组、复发SNIP组、恶变SNIP组及SCC组。利用免疫组织化学染色技术检测MMP-9、PCNA在各组中的表达情况。结果：MMP-9、PCNA在良性SNIP组、复发SNIP组、恶变SNIP组及SCC组中的表达逐渐增强，经秩和检验两两比较，显示MMP-9的表达在良性SNIP组与复发SNIP组，良性SNIP组与恶变SNIP组，良性SNIP组与SCC组之间均有显著性差异，复发SNIP组与恶变SNIP组，复发SNIP组与SCC组，恶变SNIP组与SCC组之间无明显差异；PCNA的表达在各组间差异无显著性。结论：MMP-9、PCNA的表达参与SNIP的发病，并在其复发和恶变中起重要作用，可能是SNIP复发和恶变的早期事件之一。

Abstract: Objective: To explore the function of MMP-9 and PCNA in the occurrence, recurrence and malignancy of the sinonasal inverted papilloma (SNIP). Methods: Forty specimens with SNIP and ten specimens with squamous cell carcinoma (SCC) were selected for this study. All the specimens were divided into four groups: the SNIP group, the recurrent SNIP group, the SNIP with carcinoma group, and the invasive squamous cell carcinoma (SCC) group. The expression of MMP-9 and PCNA was determined by using an immunohistochemistry method. The results were analyzed by a quantitative immunohistochemical analysis. Results: Expression of increased in the SNIP group, the recurrent SNIP group, the SNIP with carcinoma group, and the SCC group. According to the rank test, the expression of MMP-9 was significantly different between the SNIP group and other groups. But between recurrent SNIP and SNIP with carcinoma, recurrent SNIP and SCC, SNIP with carcinoma and SCC, there were no prominent differences. The expression of PCNA was not significantly different between any two groups. Conclusion: The expression of MMP-9 and PCNA is involved in the mechanism of the occurrence of SNIP and plays an important role in the recurrence and malignancy of SNIP. The over expression of MMP-9 and PCNA may be associated with early events in the recurrence tendency and carcinogenesis/transformation to SNIP.

Key words: Nose neoplasms, Nasal cavity, Paranasal sinuses, Gelatinase B, Proliferating cell nuclear antigen, Immunohistochemistry

中图分类号:

R739.62

刘　鹤,邹　雪,李　敏,吴晓娟,张立强,叶　萍,李学忠 . 鼻腔鼻窦内翻性乳头状瘤中MMP-9、PCNA的表达及临床意义[J]. 山东大学学报(医学版), 2007, 45(3): 233-237.

LIU He,ZOU Xue,LI Min,WU Xiao-juan,ZHANG Li-qiang,YE Ping,LI Xue-zhong. Expression of MMP-9 and PCNA in sinonasal inverted papilloma and the clinical significance[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(3): 233-237.

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