通心络与辛伐他汀稳定兔易损斑块的疗效对比

山东大学学报(医学版)

通心络与辛伐他汀稳定兔易损斑块的疗效对比

鹿晓婷¹，张蕾²，刘燕¹，刘运芳³，燕芳芳¹，赵玉霞¹

山东大学 1. 齐鲁医院中医科; 2. 齐鲁医院心内科; 3. 医学院诊断学教研室，济南 250012

收稿日期:2007-07-25 修回日期:1900-01-01 出版日期:2007-12-24 发布日期:2007-12-24
通讯作者: 赵玉霞

Effects of Tongxinluo and Simvastatin on vulnerable plaques in rabbits: a comparison study

LU Xiao-ting¹，ZHANG Lei²，LIU Yan¹，LIU Yun-fang³，YAN Fang-fang¹，ZHAO Yu-xia¹

1. Department of Traditional Chinese Medicine； 2. Department of Cardiology, Qilu Hospital of Shandong University; 3. School of Medicine Department of Diagnostics, Shandong University

Received:2007-07-25 Revised:1900-01-01 Online:2007-12-24 Published:2007-12-24
Contact: ZHAO Yu-xia

摘要/Abstract

摘要： 目的对比研究通心络与辛伐他汀对兔易损斑块的稳定作用。方法30只实验兔采用球囊拉伤腹主动脉+高脂喂养建立动脉粥样硬化模型，10周末改喂普通饲料并随机分为自然消退组、通心络组、辛伐他汀组，每组10只，持续药物干预12周，22周末斑块局部转染携带p53的复制缺陷型重组腺病毒载体，24周末，应用蝰蛇毒、组胺触发。检测血脂并进行体表超声、声学密度和病理学检测。结果通心络组和辛伐他汀组与自然消退组比较，血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)（P＜0.01）、腹主动脉内中膜厚度（IMT）（P＜0.05，P＜0.01）均显著降低；内中膜校正回声强度（AIIc %）显著升高（P＜0.05～0.01）。辛伐他汀组与通心络比较，TC水平降低（P＜0.01）。结论通心络和辛伐他汀一样具有稳定易损斑块的作用，且疗效相当。

关键词: 辛伐他汀 , 通心络, 易损斑块

Abstract: Objective To compare the stabilizing effects of Tongxinluo and simvastatin on vulnerable plaques in rabbits. Methods30 rabbits were subjected to ballooninduced abdominal aortic wall injuries and then were fed with a dietary of 1% cholesterol. After 10 weeks induction, they were randomly divided into three groups: the regression group, the Tongxinluo group and the simvastatin group. At the end of week 24, recombinantp53 adenoviruses were locally delivered to the atherosclerotic plaques and plaque rupture was triggered by the intraarterial viper venom and histamine. The serum lipids, the high frequency duplex, the acoustic densitometry and the pathologic staining were all determined. ResultsCompared with the regression group, TC, LDL-C（P＜0.01）and IMT （P＜0.050.01）in the Tongxinluo group and the simvastatin group were significantly decreased while the AIIc %（P＜0.050.01）was significantly increased. The TC level in the simvastatin group was lower than that in the Tongxinluo group（P＜0.01）. Conclusion Both Tongxinluo and simvastatin can increase the stability of atherosclerosis in rabbits with vulnerable plaques.

Key words: Vulnerable plaque, Tongxinluo, Simvastatin

鹿晓婷,张蕾,刘燕,刘运芳,燕芳芳,赵玉霞 . 通心络与辛伐他汀稳定兔易损斑块的疗效对比[J]. 山东大学学报(医学版), 2007, 45(12): 1205-1208.

LU Xiao-ting,ZHANG Lei,LIU Yan,LIU Yun-fang,YAN Fang-fang,ZHAO Yu-xia. Effects of Tongxinluo and Simvastatin on vulnerable plaques in rabbits: a comparison study[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(12): 1205-1208.

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