磁共振弥散张量成像对Wallerian变性诊断价值的评价

山东大学学报(医学版)

磁共振弥散张量成像对Wallerian变性诊断价值的评价

崔谊，侯金文，孟祥水，刘影，张凯

山东大学齐鲁医院放射科，山东济南 250012

收稿日期:2005-10-10 修回日期:1900-01-01 出版日期:2006-07-24 发布日期:2006-07-24
通讯作者: 崔谊

CUI Yi,HOU Jin-yi,MENG Xiang-shui,LIU Ying,ZHANG Kai

Received:2005-10-10 Revised:1900-01-01 Online:2006-07-24 Published:2006-07-24
Contact: CUI Yi

摘要/Abstract

摘要： 目的：探讨磁共振弥散张量成像技术（diffusion tensor imaging, DTI）在Wallerian变性中的诊断价值。方法:对40例正常志愿者、10例正常变异者和 40例病变者分别进行DTI和常规MRI扫描。结果：正常志愿者大脑脚、脑桥基底部皮质脊髓束走行区各向异性分数（fractional anisotropy, FA）均值分别为0.73和0.63，其FA比值（数值小的一侧比大的一侧）分别为97.6%和96.8%；正常变异者大脑脚、脑桥基底部皮质脊髓束走行区FA均值分别为0.72和0.64，其FA值比值分别为96%和95%，与正常志愿者相比，差异无统计学意义（P＞0.05）；病变者患侧大脑脚、脑桥基底部FA均值分别为0.64及0.52。其FA比值（患侧FA值比健侧FA值）分别为76.0%和77.0%，患侧大脑脚、脑桥基底部皮质脊髓束的FA值及其比值较正常者明显减小,差异有统计学意义（P＜0.05）。结论：DTI技术通过测量FA值及其比值及神经纤维束的三维重建，较常规MRI更为准确客观地诊断Wallerian变性。

Abstract: To explore the value of the diffusion tensor imaging (DTI) in diagnosing Wallerian degeneration. Methods: DTI and MRI protocols were performed on 40 healthy volunteers, 10 normal variants and 40 patients, respectively. Results: The mean FA ratios of the corticospinal tracts in cerebral peduncle and basilar part of pons were 0.73 (97.6%) and 0.63 (96.8%) in 40 healthy volunteers, and they were 0.72 (96.0%) and 0.64 (95.0%) in 10 normal variants; No significant difference was found between the healthy volunteers and normal variants (P＞0.05). Whereas, they were 0.64(77.0%) and 0.52(76.0%) in 40 patients, significantly reduced compared with the healthy volunteers and the normal variants（P＜0.05）. Conclusion: DTI is more accurate than MRI in diagnosing Wallerian degeneration.

Key words: Wallerian degeneration, Diffusion tensor imaging, Magnetic resonance imagingWallerian

崔谊,侯金文,孟祥水,刘影,张凯. 磁共振弥散张量成像对Wallerian变性诊断价值的评价[J]. 山东大学学报(医学版), 2006, 44(7): 746-749.

CUI Yi,HOU Jin-yi,MENG Xiang-shui,LIU Ying,ZHANG Kai. [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2006, 44(7): 746-749.

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