Abstract:

Objective    To investigate the relationship between 25-OH-VitD and obesity related metabolic disorders, and determine the effect of vitamin D supplementation on the disorders. Methods    A cohort of 201 obese subjects was divided into the obesity group and the obesity with metabolic syndrome group. Height and weight were measured, and body mass indexes(BMI) were calculated. Levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and fasting plasma glucose were determined. Serum 25-OH-VitD and fasting insulin concentrations were measured by radioimmunoassay. 88 obese subjects with metabolic syndrome complicated by vitamin D deficiency were subdivided into the treatment group and the control group. Both groups received life style intervention for weight loss for 12 weeks. At the same time, the treatment group received oral administration of vitamin D. The level of serum 25-OH-VitD and metabolic parameters were measured at the baseline and after the treatment. Results    There was no significant difference in the level of serum 25-OH-VitD between the obesity group and the obesity with metabolic syndrome group（P>0.05). The level of serum 25-OH-VitD has a significantly negative association with individual BMI and triglyceride level（P<0.05). After 12week intervention, a significant decrease in triglyceride level was observed in the treatment group compared with the control group（P<0.05). ConclusionsHypovitaminosis D is associated with BMI and triglyceride level in overweight/obese subjects in China, and the vitamin D supplementation can enhance the beneficial effect of weight loss on lipid disorders in overweight/obese subjects with metabolic syndrome.

Key words: Obesity; Vitamin D; Metabolic syndrome