Abstract:

Objective    To investigate clinical significances of apolipoprotein and C-reactive protein in elderly diabetic patients complicated by cerebral infarction. Methods    47 elderly patients with diabetic acute cerebral infarction(the DACI group) and 45 elderly patients without diabetic acute cerebral infarction(the NDACI group) were involved. Levels of total cholesterol(TC), triglycerides(TG),high density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), Apo lipoprotein A-I (ApoA-I) and Apo lipoprotein B (ApoB) were measured with the enzyme method. The level of high sensitive C-reactive protein（hs-CRP）was measured with the scatter immune turbidity method. The indexes were compared. Results    Levels of TC, TG, LDL-C and ApoB in the DACI group were significantly higher than those in the NDACI group(P<0.01), while levels of HDL-C and ApoA-I were significantly lower(P<0.01).  hs-CRP level in the DACI group was significantly higher than that in the NDACI group(P<0.05). Conclusion     Levels of ApoA-I, ApoB and hs-CRP are closely associated with cerebral infarction, and can be considered as high-risk predictors for diabetes mellitus complicated by cerebral infarction.

Key words: Apolipoprotein; C-reactive protein; Diabetes mellitus; Cerebral infarction; Elderly