Abstract:

Objective  To investigate the clinical effect of continuous ultrafiltration in open heart surgery with cardiopulmonary bypass (CPB) for infants. 
 Methods  Fifty patients with congenital heart defects were randomly divided into two groups. In the control group, conventional CPB was used without ultrafiltration.In the treatment group, in addition to the same CPB, continuous ultrafiltration was used throughout CPB. Serum concentrations of interleukin-6(IL-6) and tumor necrosis factor(TNF), hematocrit(HCT), serum albumin concentrations, pulmonary function and the recovery time after the operations were measured.    Results  Serum concentrations of IL-6 and TNF were significantly decreased, HCT and serum albumin concentrations were significantly increased, pulmonary function was improved and the recovery time after the operations was shortened in the treatment group compared with the control group (P<0.05).  Conclusion Continuous ultrafiltration can effectively exclude some harmful inflammatory mediators, concentrates the blood, attenuates lung edema and injuries, and promotes recovery after operations.

Key words: ongenital heart defects； Infants;  Cardiopulmonary bypass;  Ultrafiltration