Abstract:

Objective  To determine expressions of PTEN and p-Akt in different stages of infantile hemangioma, and to explore the correlation between PTEN and p-Akt and approach significance of PTEN and p-Akt in the occurrence and development of infantile hemangioma.  Methods  Expressions of PTEN and pAkt were determined by SP immuno histochemical technique in cases of proliferating hemangiomas, involuting hemangiomas, vascular malformations, and normal skins. Mean optical density was measured by an image analysis system.  Results  Expression of PTEN in proliferating hemangiomas was lower than in the other groups (P<0.01). Expression of p-Akt in proliferating hemangiomas was higher than in the other groups (P<0.05). No statistical difference was found in expressions of PTEN and p-Akt among involuting hemangioma, vascular malformation and normal skins. Expression of PTEN was negatively correlated with expression of p-Akt (r=－0.719?2,P＜0.05).  Conclusion  PTEN and p-Akt may play important roles in the proliferating phase of infantile hemangioma.

Key words: Hemangioma; Phosphatase and tensin homologue deleted on chromosome 10; Akt