JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES) ›› 2009, Vol. 47 ›› Issue (5): 92-.

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Expression of programmed cell death factor 10 protein and its clinicopathological significance in gastric cancer

 ZHU Xiao-Yan, WANG De-Rong, QU Fei   

  1. 1. School of Medicine, Shandong University, Jinan 250012， China;2. Depantment of Gastroenterology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China；3. Depantment of Pathology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China
  • Received:2008-11-11 Online:2009-06-16 Published:2009-05-16

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Abstract:

Objective  To investigate expression of programmed cell death factor 10 (PDCD10) protein and its clinicopathological significance in the progress of gastric cancer.  Methods Expression of PDCD10 was determined by the SP immunohistochemical method in 26 cases of normal gastric mucosa, 22 cases of chronic atrophic gastritis with intestinal metaplasia and 66 cases of gastric carcinoma. Relationship between expression of PDCD10 and clinicopathological characters of gastric carcinoma was analyzed.  Results  The positive rates of expression in normal gastric mucosa, chronic atrophic gastritis with intestinal metaplasia and gastric carcinoma were 11.5%, 31.8% and 63.6% respectively，which was progressively upregulated. In gastric cancer, expression was not related to sex, age, and site of tumors (P＞0.05), in contrast, positive rates were related to the degree of differentiation clinical stages, lymph nodes and distant metastases (P＜0.05).  Conclusion   PDCD10 expression in gastric cancer tissues is significantly higher than that in the normal gastric mucosa and chronic atrophic gastritis with intestinal metaplasia tissues. There is a correlation between expression of PDCD10 and histological grades and metastases of gastric cancer.

Key words: Programmed cell death factor 10; Gastric neoplasm; Apoptosis

CLC Number: 

  • R735.2
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