JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• 无栏目 • Previous Articles     Next Articles

Aerobic exercise protects rats with chronic unpredictable mild stress against acute stress

LIU Xin， YANG Lejin， FAN Shujuan, JIANG Hong, PAN Fang
   

  1. (Department of Medical Psychology, School of Medicine, Shandong University, Jinan 250012, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-02-16 Published:2009-02-16
  • Contact: PAN Fang

PDF (PC)

795

Abstract: To explore the protection of aerobic exercise on behavior and endocrine immunity in chronic unpredictable mild stress (CUMS) rats exposed to acute stress. Methods29 healthy male Wistar rats were randomly divided into four groups: the control group, the CUMS model group, the stress with aerobic exercise group, and the stress with labetalol group. Models were produced by a chronic unpredictable mild stress of 21 days. Aerobic exercise and labetalol were used for antistress. After the process of 21 days′ CUMS, acute stress was given. All the rats′ openfield activities were investigated, and serum cortisol and IL1β concentrations were determined by radioimmunoassays. ResultsBehaviors of the CUMS model group had depressive changes. Aerobic exercise not only improved the behavior of CUMS rats but also increased the serum cortisol to a quite normal level, which was higher than that of the CUMS model group and the labetalol group. Labetalol improved the crossings of CUMS rats, while other behavior indexes changed to the contrary. There was no statistical discrepancy of IL1β among groups. ConclusionAerobic exercise could protect CUMS rats against acute stress, which is much better than adrenergic receptor antagonist.

Key words: Stress, Aerobic exercise, Receptor,adrenergic, Behavioral Sciences, Hydrocortisone, Rat,Wistar

CLC Number: 

  • R395.1
[1] WANG Ye, WANG Gang, NAN Haiou, CAI Yuling, LI Jiayu, WANG Haifeng, YAN Yingjie, JIANG Zhiwei. Correlation between perioperative heart rate variability and inflammatory indicators in gastric cancer patients [J]. Journal of Shandong University (Health Sciences), 2026, 64(4): 23-30.
[2] ZHENG Jinai, WANG Yanmei, QU Yan, LI Liwei, LIU Yong, ZHANG Yuan. Mediating effect of perceived stress between mindfulness and demoralization syndrome in maintenance hemodialysis patients [J]. Journal of Shandong University (Health Sciences), 2026, 64(4): 109-116.
[3] YU Haozhi, SHI Guidong, XU Guopeng, JIANG Yunpeng, FENG Shiqing, LIU Xinyu, QI Lei. Research progress of antioxidant carbon dot nanozymes to regulate the neuro-regeneration microenvironment [J]. Journal of Shandong University (Health Sciences), 2026, 64(2): 44-49.
[4] WANG Yueqi, SONG Dongyu, LI Yuli, XIE Hao, ZHANG Yuerong. Mediating role of childrens difficulties and prosocial behaviour in the relationship between family resilience and grandparenting stress [J]. Journal of Shandong University (Health Sciences), 2026, 64(1): 57-64.
[5] WANG Liyun, GAO Tianqin, LIU Yujia, CHEN Qing, CHEN Liu, SHA Kaihui. Development and validation of a postpartum stress urinary incontinence risk prediction model based on machine learning [J]. Journal of Shandong University (Health Sciences), 2025, 63(6): 55-66.
[6] XU Jingjing, WANG Xinqi, ZHANG Yang, XU Wangwang, GAO Jin. Effects of P2X7 receptor inhibitors on behaviour and gut microbiota in adolescent rats with post-traumatic stress disorder [J]. Journal of Shandong University (Health Sciences), 2025, 63(4): 1-9.
[7] CAI Jiaying, WANG Jingting, WANG Zengping, WANG Jing, JIA Yanfei, MA Xiaoli. Effect of α5-nAChR on the expression of c-Fos in nucleus ambiguus in chronic stress-induced lung adenocarcinoma mice [J]. Journal of Shandong University (Health Sciences), 2025, 63(4): 69-74.
[8] LI Xiang, ZHANG Yi, WANG Xuechun, XU Mengchao, WANG Yuelan. Research progress on oxidative stress in acute lung injury induced by traumatic brain injury [J]. Journal of Shandong University (Health Sciences), 2025, 63(2): 118-124.
[9] LIU Wenzhao, ZHANG Yuan, MA Xiangping, WEI Fengtao, BU Peili. Correlation between the pre-endothelial activation and stress index and the mortality risk of patients with heart failure [J]. Journal of Shandong University (Health Sciences), 2025, 63(11): 27-35.
[10] SUN Lina, BAI Hongyan, NIU Zongge, ZHANG Fushuai, QU Yiqing. Construction and evaluation of an online clinical risk model for predicting in-hospital mortality in patients with ARDS based on SII [J]. Journal of Shandong University (Health Sciences), 2024, 62(7): 10-20.
[11] ZHU Hongting, REN Minmin, WANG Hui, SUN Xiangjie, FENG Danjun. Effects of occupational stress on quality of life among nurses: a moderated mediation model [J]. Journal of Shandong University (Health Sciences), 2024, 62(1): 89-94.
[12] HU Yanwen, ZHAO Huichen, MA Xiaoli, LIU Yuantao, ZHANG Yuchao. GLP-1 inhibits oxidative stress damage through cytochrome P450 surface oxidase pathway [J]. Journal of Shandong University (Health Sciences), 2023, 61(8): 10-16.
[13] YAN Congcong, CHEN Chen, XIE Qian, WANG Yanan, ZHANG Xinlu, ZHANG Yingchun, WU Bin. Effects of bisphenol A exposure on m6A modification level of KGN cells [J]. Journal of Shandong University (Health Sciences), 2023, 61(8): 17-23.
[14] LIU Yang, CHEN Guihai. Effects and mechanism of Hanjingtang on the oxidative stress induced by cold stimulation in aortic vascular smooth muscle cells [J]. Journal of Shandong University (Health Sciences), 2023, 61(8): 24-30.
[15] QI Shaojun, TANG Yanjin, ZHANG Zhengduo, WU Hong, ZHANG Jiacheng, QIN Chuan, LIU Rui, GAO Xibao. Protective effects of supplementing various trace elements on rats with high-sucrose diet [J]. Journal of Shandong University (Health Sciences), 2023, 61(7): 19-26.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd