Abstract:

Objective〓〖WTBZ〗To investigate the application of computed tomography perfusion imaging（CTPI）combined with determination of Glu and GABA in the plasma in diagnosis of acute cerebral infarction (CI). 〖WTHZ〗Methods〓〖WTBZ〗57 patients with acute cerebral infarction onset within 24 hours were examined by conventional CT and CTPI. CTPI yielded a set of relative cerebral blood flow(rCBF), mean transmit time(MTT) and time to peak(TP). By mean of highperformance liquid chromatography, the levels of Glu and GABA in the plasma of all patients were determined. 〖WTHZ〗Results〓〖WTBZ〗Conventional CT scan showed a low-density signal in 26 of 57 patients. CTPI revealed normal perfusion in 3 patients and hypo-perfusion in 54 patients. The regional cerebral blood flow（rCBF）, time to peak（TP）, and mean transit time（MTT）were obviously changed in 54 patients by CTPI. The ischemic lesion side as compared with the opposite side, and the core of the ischemic lesion as compared with the peripheral zone were significantly changed（P＜0.05）. A linear correlation analysis showed that there were positive correlations between infarction volume and plasma levels of Glu and GABA (r=0.88, P＜0.01; r=0.47, P＜0.01) and the infarction volume. 〖WTHZ〗Conclusion〓〖WTBZ〗CTPI combined with determination of Glu and GABA in plasma can be used in diagnosis of early stage of cerebral infarction and measurement of infarct volume, so it is great for prognosis and treatment.

Key words: Cerebral infarction, Tomography, X-ray computed, Glutamic acid, γ-aminobutyric acid