Abstract: To study the effects of Fuganling (FGL) in protecting immunity hepatic injury induced by Bacille calmette guerin(BCG) and Lipopolysaccharide (LPS) in mice. MethodsA total of 50 mice were viscerally injected with BCG and LPS to establish the immunological liver injury model, then they were divided into 5 groups: 4 experimental groups were given 100mg／kg, 50mg／kg, 25mg／kg FGL or 80mg／kg LianBenShuangZhi through a tube feeding, and the model control group was given normal saline. 10 mice without injections served as the normal control group. The indexes of the thymus, liver and spleen were determined, also the activities of alanine aminotransferase(ALT), and aspartate aminotransferase (AST) in the serum were determined. ResultsCompared to the normal control group, the thymus index of the model control group significantly decreased, and the liver index and the spleen index significantly increased, also the activities of ALT and AST in the serum increased in a large scale(P＜0.01). However, the activities of ALT and AST in the three model groups treated with FGL were significantly decreased, and the thymus index was significantly increased in the high dose and medium dose FGL groups(P＜0.01). ConclusionsThe mouse immunity hepatic injury model was successfully induced by BCG and LPS. FGL has a remarkably protective effect on immunity hepatic injury.

Key words: Fuganling granule, Immunological liver injury, Bacille calmette guerin(BCG), Lipopolysaccharide(LPS), Mice