Abstract: To study the efficacy of remifentanil or/and lornoxicam in reducing the adverse effects during recovery from general anesthesia. MethodsSixty ASA Ⅰ to Ⅱ patients aged 18 to 60 years who experienced oral or maxillofacial operations, were divided into four groups(n=15): group Ⅰ (remifentanil infusion was stopped at the end of the operations), group Ⅱ(remifentanil infusion turned into 0.05μg/(kg·min) after the completion of the operations and remained till extubation), group Ⅲ (8 mg lornoxicam was intravenously administered at 20 min before introduction and 30 min before the completion of the operations), and group Ⅳ( remifentanil was used as group Ⅱ and lornoxicam was used as group Ⅲ). Anesthetic induction and maintenance were the same in the four groups. The rate of restlessness and cough during recovery, the time of opening eyes when called, the time of extubation, blood pressure (BP), heart rate (HR) at completion of the operations, extubation, and 5 and 10min after extubation, and the scores of verbal rating scale (VRS) at 5 and 10 min after extubation were determined. ResultsThe cough rate in groups Ⅱ and Ⅳ was lower than that in group Ⅰ（P＜0.05）， the times of opening eyes and of extubation were also longer than those in group Ⅰ（P＜0.05）. The BP and HR in groups Ⅱ, Ⅲ and Ⅳ were significantly lower than those in group Ⅰ at extubation and 5 min after extubation （P＜0.05 or P＜0.01）, also they were lower in groups Ⅲ and than in groups Ⅰ at 10 min after extubation (P＜0.05 or P＜0.01）, but they were steady in group Ⅳ during the recovery. The VRS scores were remarkably lower in group Ⅱ, Ⅲ and Ⅳ than in group Ⅰ at 5 min after extubation（P＜0.05）and were significantly lower in group Ⅲ and Ⅳ than in group Ⅰ and Ⅱ at 10 min after extubation（P＜0.05）. ConclusionAdministered remifentanil or lornoxicam can reduce adverse effects during recovery from general anesthesia, and their combination makes extubation comfortable, painless and safe.

Key words: Remifentanil, Lornoxicam, General anesthesia, Pain, Extubation