Abstract: Objective: To observe the effects of rhG-CSF and VEGF on the cognition disorders of senescence accelerated mouse P10 (SAM-P10). Methods： Seventy-two SAM-P10 were randomly divided into control group, rhG-CSF group, and rhG-CSF combined with VEGF group. Mice in rhG-CSF group were subjected to 100μg/(kg·d) rhG-CSF subcutaeneouslly for 7 days, while mice in the rhG-CSF combined with VEGF group were first subjected to 50μg/(kg·d) VEGF intraperitoneally for 3 days and then 50?μg/(kg·d) rhG-CSF subcutaeneouslly for 7 days. Mice in the control group were subjected to normal saline. The Morris water maze test was applied before an administration and on the 7th, 14th, 28th, and 56th day after an administration to observe the changes of the cognitive ability. Results： The ability of learning and memory declined in the control group. Compared with the control group, the escaping latency declined and the percentage of swimming distance in the target quadrant increased both in the rhG-CSF group and in the rhG-CSF combined with VEGF group，moreover, the above items were better in the rhG-CSF combined with VEGF group than in the rhG-CSF group(P＜0.05). Conclusion： rhG-CSF combined with VEGF is able to improve the cognition disorders of SAM-P10.

Key words: Granulocyte colony stimulating factor, Vascular endothelial growth factor, Senescence accelerated mouse, Morris water maze, Cognition disorders