JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effect of long-term ethanol feeding on glycogen and structures of the livers of Wistar rats

CHEN Shao-hua1,3,ZHAO Jia-jun1，FENG Li1,HOU Xiao-lei2，ZHANG Wei3,YU Hui3，GAO Ling2   

  1. 1. Department of Endocrinology, Shandong Provincial Hospital; 2. Institute of Pharmacology, Shandong Provincial Hospital; 3.Department of Endocrinology, Qianfoshan Hospital of Shandong Province
  • Received:2007-06-24 Revised:1900-01-01 Online:2007-11-24 Published:2007-11-24
  • Contact: CHEN Shao-hua

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Abstract: ObjectiveTo investigate the effects of a long-term ethanol feeding on the glycogen content and structure of the liver in rats. Methods48 rats were randomly divided into 4 groups: the ethanol groups A, B and C and the control group. Rats were subjected to ethanol of 0.5, 2.5, and 5g/(kg·d) in the experimental groups respectively and saline in the control group for 5 months. Different physical parameters, HE staining, PAS staining and the glycogen content( Colorimetry, SpectraMax M2，) were determined. ResultsCompared with group D, groups A, B and C showed a lower weight of body and liver. Glycogen levels of groups A, B and C decreased, and the glycogen decreased in an ethanol dosedependent manner. HE staining showed lots of lipid vacuoles and inflammatory cells in groups A, B and C relative to group D. On the other hand, PAS staining revealed a decrease of glycogen granules. ConclusionLong-term intake of ethanol influences the glycogen content and causes some damage to the structure of liver tissues.

Key words: Ethanol, Liver, Glycogen, Wistar rats

CLC Number: 

  • R575.5
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