JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

• Articles • Previous Articles     Next Articles

Progesterone combined with octreotide inhibits the growth of human non-small cell lung cancer A549 cells

SUN Mei-li, WANG Xiu-wen, WEI Jun-min   

  1. Center for Tumor Treatment and Prevention, Qilu Hospital of Shandong University, Jinan250012, Shandong, China
  • Received:2006-09-04 Revised:1900-01-01 Online:2007-01-24 Published:2007-01-24
  • Contact: WANG Xiu-wen

PDF (PC)

728

Abstract: Objective: To investigate the regulation of somatostatin recepter (SSTR) subtype mRNAs expression of non-small cell lung cancer cell line A549 by progesterone and the antiproliferation of progesterone combined with octreotide on A549 cells. Methods: The progesterone receptor was detected by the immunohistochemical method, and SSTR subtype mRNAs were determined by the reverse transcription polymerase chain reaction in cells pretreated or non-pretreated by progesterone. The cell viability was evaluated by MTT assay. Results: Progesterone receptor and SSTR1, SSTR2, SSTR4 and SSTR5 were revealed in A549 cells, but SSTR3 was not. Following 24-hour treatment by 10nmol/L progesterone, SSTR3 was detected in A549 cells. Up to 48 hours, SSTR3 was still up-regulated(P＝0.012). Progesterone combined with octreotide was superior to progesterone or octreotide alone in inhibiting the growth of A549 cells(P<0.05). Conclusion: Progesterone up-regulates the expression of mRNA for SSTR subtypes in A549 cells. Progesterone enhances the ability of octreotide to inhibit the growth of A549 cells.

Key words: Carcinoma, non-small cell lung, Somatostatin receptor, Progesterone

CLC Number: 

  • R737.33
[1] YU De-Xin, CAEI Ti-Gong, MA Xiang-Xing, ZHANG Xiao-Ming, LI Chuan-Fu. Angiogenesis and maturation of hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 51-54.
[2] WANG Shao-Qing, LIU Yi-Hui, FU Ting-Ting, CHENG Jin-Yong, LIU Qiang. Classification of 31P MRS data for hepatocellular carcinoma [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 42-46.
[3] LV Yan-Feng, DING Ke, WANG Jian-Xin, YU Hua-Long, BEI Shao-Sheng. Canceration of chronic anal fistula [J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2209, 47(6): 55-57.
[4] LI Jingxiu, LI Zhonghui, LI Wentian, WANG Yunan, SONG Zehui, ZHUANG Dayong, HE Qingqing, ZHOU Peng. Preliminary application of photoelectric detection devices in thyroid cancer surgery [J]. Journal of Shandong University (Health Sciences), 2026, 64(4): 31-37.
[5] HUANG Peiwen, WANG Xudong. A new drug for non-small cell lung cancer: Telisotuzumab Vedotin, an antibody-drug conjugate targeting c-Met protein [J]. Journal of Shandong University (Health Sciences), 2026, 64(3): 124-130.
[6] YIN Yue, MO Zhenfei, WU Peixin, LIU Jinxia, WEI Yuanhui, REN Jiabo, LI Chunsun. Expression of GPX1 in lung cancer cell lines and its influence on the proliferation, migration, invasion abilities and apoptosis in lung adenocarcinoma cell lines [J]. Journal of Shandong University (Health Sciences), 2026, 64(1): 65-73.
[7] HAN Jueming, WANG Hui, WU Qian, ZHENG Huiling, ZHU Lin. B4GALNT4 promotes proliferation, migration and invasion of lung adenocarcinoma cells [J]. Journal of Shandong University (Health Sciences), 2025, 63(7): 23-31.
[8] ZHAO Hanqing, ZHOU Xinrui, LI Zijian, TANG Xing. Application of circulating tumor cells combined with serological detection in non-small cell lung cancer [J]. Journal of Shandong University (Health Sciences), 2025, 63(5): 79-85.
[9] WANG Xiaolei, FANG Jun, WANG An, ZHU Wuhui, SHI Guangjun. Two-sample Mendelian randomization of the relationship between gut microbiota and the risk of extrahepatic cholangiocarcinoma [J]. Journal of Shandong University (Health Sciences), 2025, 63(4): 44-50.
[10] CAI Jiaying, WANG Jingting, WANG Zengping, WANG Jing, JIA Yanfei, MA Xiaoli. Effect of α5-nAChR on the expression of c-Fos in nucleus ambiguus in chronic stress-induced lung adenocarcinoma mice [J]. Journal of Shandong University (Health Sciences), 2025, 63(4): 69-74.
[11] XU Nianxing, WEI Dong, QIAO Junjie, ZHAN Bingyan. Predictive value of CD8+, IL-6, and PaO2 for immunotherapy-triggered radiation recall pneumonitis in unresectable stage ⅢB/C and IV non-small cell lung cancer [J]. Journal of Shandong University (Health Sciences), 2025, 63(2): 29-35.
[12] Thoracoscopic Committee of Shandong Provincial Endoscopic Surgery Quality Control Center. Shandong Provincial expert consensus on control indexes of VATS/RATS perioperative quality for non-small cell lung cancer [J]. Journal of Shandong University (Health Sciences), 2025, 63(12): 1-5.
[13] GONG Jie, YU Miao, LI Xiuyong, CHEN Ying, XU Qianru, LI Meijuan, LI Yitong, LIU Xiumei. Construction of polysaccharide probe based on upconversion nanoparticles and its application in tumor bioimaging [J]. Journal of Shandong University (Health Sciences), 2025, 63(11): 18-26.
[14] LIU Zhenkun, LYU Jiling, XU Weiwei, MA Litian, ZHANG Caiqing. Value of tNGS testing and conventional culture for BALF in the diagnosis of NSCLC complicated with IPFD [J]. Journal of Shandong University (Health Sciences), 2025, 63(11): 36-45.
[15] HAO Xiaomeng, YU Zeyuan, ZHANG Xiaofang. Gastric mucinous adenocarcinoma of lung has unique clinical and pathological characteristics [J]. Journal of Shandong University (Health Sciences), 2024, 62(8): 107-116.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Journal of Shandong University (Health Sciences)
Supported by Beijing Magtech Co.Ltd