铁死亡在腹主动脉瘤中的研究进展

doi:10.6040/j.issn.1671-7554.0.2024.0496

摘要/Abstract

摘要： 腹主动脉瘤在高龄人群中发病率高、破裂风险大,是血管外科常见的危重急症,然而目前还缺少腹主动脉瘤有效的治疗药物或靶点。铁死亡是近几年新发现的一种可调控的细胞死亡方式,特点是依赖于铁离子和脂质过氧化物堆积。铁死亡广泛参与了心血管、肿瘤、神经系统等多种疾病的发生发展,本文回顾近5年铁死亡与腹主动脉瘤的相关研究进展,总结铁死亡的主要机制及其在腹主动脉瘤中的作用,发现铁死亡可能通过影响血管平滑肌细胞的衰老、死亡和表型转换等来参与腹主动脉瘤的进展,提出铁死亡有望成为腹主动脉瘤防治的新靶点。

关键词: 铁死亡, 腹主动脉瘤, 血管平滑肌细胞, 氧化

Abstract: Abdominal aortic aneurysm is a common critical emergency in vascular surgery with a high incidence and a high risk of rupture in the elderly population. However, there is still a lack of effective therapeutic drugs or targets for abdominal aortic aneurysm. Ferroptosis is a newly discovered regulated cell death mode in recent years, characterized by its dependence on the accumulation of iron ions and lipid peroxides. Ferroptosis is widely involved in the development of cardiovascular, neoplastic, neurological and other diseases. This article summarizes the main mechanism of ferroptosis and its role in abdominal aortic aneurysm by reviewing the progress of research related to ferroptosis and abdominal aortic aneurysm in the past five years. Ferroptosis may be involved in the progression of abdominal aortic aneurysm by affecting the senescence, death and phenotype transition of vascular smooth muscle cells, suggesting that ferroptosis may be a new target for the prevention and treatment of abdominal aortic aneurysm.

Key words: Ferroptosis, Abdominal aortic aneurysm, Vascular smooth muscle cell, Oxidation

中图分类号:

R543.1

牛帅,吴学君. 铁死亡在腹主动脉瘤中的研究进展[J]. 山东大学学报 (医学版), 2024, 62(9): 74-79.

NIU Shuai, WU Xuejun. Research progress of ferroptosis in abdominal aortic aneurysm[J]. Journal of Shandong University (Health Sciences), 2024, 62(9): 74-79.

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