淄博市2018年恶性肿瘤的流行特征及影响因素

doi:10.6040/j.issn.1671-7554.0.2021.0672

摘要/Abstract

摘要： 目的探讨山东省淄博市恶性肿瘤的流行特征,分析发病率与影响因素的相关性,为淄博市恶性肿瘤防控及相关政策的制定提供参考依据。方法基于淄博市2018年恶性肿瘤发病报告数据,采用空间自相关统计方法进行全局及局部聚集性分析,分析淄博市恶性肿瘤流行特征;采用Spearman等级相关分析发病率与影响因素的相关性。结果淄博市2018年恶性肿瘤报告发病人数为17 379人,粗发病率为383.55/10万,发病主要集中在55岁及以上年龄组,高发职业人群为农、林、牧、渔、水利业生产者。淄博市各乡镇恶性肿瘤发病例数存在一定的空间聚集性,聚集热点集中在张店区和桓台县的部分乡镇,且与PM_2.5高浓度区域空间分布一致。相关分析结果显示,人均可支配收入与恶性肿瘤发病率呈正相关(r_s=0.86,P=0.01),高GDP地区PM_2.5浓度与恶性肿瘤发病率呈正相关(r_s=1.00,P<0.01)。结论淄博市恶性肿瘤发病数和发病率仍较高,但分布区域相对集中,建议重点地区重点关注。当地应加强环境治理,针对重点人群进行早诊早治,降低恶性肿瘤的病死率和疾病负担。

关键词: 恶性肿瘤, 淄博市, 流行特征, 空间自相关

Abstract: Objective To explore the epidemiological characteristics of malignant tumors in Zibo City, Shandong Province, and to analyze the correlation between the incidence and influencing factors, so as to provide a scientific basis for the prevention and control of malignant tumors and the formulation of relevant policies. Methods Based on the incidence data of malignant tumors in Zibo City in 2018, global and local aggregation analyses were performed with spatial autocorrelation statistical method to reveal the epidemiological characteristics of malignant tumors. Spearman rank correlation was used to analyze the correlation between the incidence and the influencing factors. Results The number of reported cases of malignant tumors was 17,379 in 2018, and the crude incidence was 383.55/100,000. The high risk group were 55 years and above, mainly working in agriculture, forestry, animal husbandry, fishing and water conservancy. The number of malignant tumor cases in each township of Zibo City had a certain spatial aggregation, especially in Zhangdian District and Huantai County, consistent with the spatial distribution of PM_2.5 high concentration area. Correlation analysis showed that the per capita disposable income was positively correlated with the incidence of malignant tumors(r_s=0.86, P=0.01), and PM_2.5 concentration was highly correlated with the incidence of malignant tumors in high GDP areas(r_s=1.00, P<0.01). Conclusion The number of cases and incidence of malignant tumors are still high in Zibo City, but the distribution area is relatively concentrated, so it is suggested to pay more attention to the key areas. Local environmental governance should be strengthened and early diagnosis and early treatment should be carried out for high risk groups to reduce the fatality rate and disease burden of malignant tumors.

Key words: Malignant tumors, Zibo City, Epidemiological characteristics, Spatial autocorrelation

中图分类号:

R181

程传龙,杨淑霞,佘凯丽,房启迪,韩闯,刘盈,崔峰,李秀君. 淄博市2018年恶性肿瘤的流行特征及影响因素[J]. 山东大学学报 (医学版), 2022, 60(2): 102-108.

CHENG Chuanlong, YANG Shuxia, SHE Kaili, FANG Qidi, HAN Chuang, LIU Ying, CUI Feng, LI Xiujun. Epidemiological characteristics and influencing factors of malignant tumors in Zibo, 2018[J]. Journal of Shandong University (Health Sciences), 2022, 60(2): 102-108.

参考文献

[1] 陈宏达, 郑荣寿, 王乐, 等. 2019年中国肿瘤流行病学研究进展[J]. 中华疾病控制杂志, 2020, 24(4): 373-379. CHEN Hongda, ZHENG Rongshou, WANG Le, et al. Progress in cancer epidemiology research in China in 2019 [J]. Chinese Journal of Disease Control & Prevention, 2020, 24(4): 373-379.
[2] 孙可欣, 郑荣寿, 张思维, 等. 2015年中国分地区恶性肿瘤发病和死亡分析[J]. 中国肿瘤, 2019, 28(1): 1-11. SUN Kexin, ZHENG Rongshou, ZHANG Siwei, et al. Report of cancer incidence and mortality in different areas of china, 2015 [J]. China Cancer, 2019, 28(1): 1-11.
[3] Raaschou-Nielsen O, Andersen ZJ, Beelen R, et al. Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects(ESCAPE)[J]. Lancet Oncol, 2013, 14(9): 813-822.
[4] 王雨燕, 王秀艳, 杜淼, 等. 淄博市重点工业行业VOCs排放特征[J]. 环境科学, 2020, 41(3):1078-1084. WANG Yuyan, WANG Xiuyan, DU Miao, et al. Emission characteristics of volatile organic compounds from typical industries in Zibo [J]. Environmental Science, 2020, 41(3): 1078-1084.
[5] 刘晓利, 王丹, 孟超, 等. 2019年淄博市城区大气PM_2.5污染状况及来源解析[J]. 现代预防医学, 2021, 48(1): 23-26,43. LIU Xiaoli, WANG Dan, MENG Chao, et al. Pollution status and source analysis of PM_2.5 in Zibo City, 2019 [J]. Modern Preventive Medicine, 2021, 48(1): 23-26,43.
[6] 张殿平, 刘芳盈, 李平, 等. 淄博市某城区大气PM_2.5中苯并[a] 芘的人群健康风险评估[J]. 环境卫生学杂志, 2020, 10(1): 38-42. ZHANG Dianping, LIU Fangying, LI Ping, et al. Health risk assessment of BaP in ambient PM_2.5 in a district of Zibo [J]. Journal of Environmental Hygiene, 2020, 10(1): 38-42.
[7] 欧盛菊, 吴丽萍, 王信梧, 等. 典型“组群式”城市夏季大气颗粒物中水溶性离子化学特征及来源[J]. 环境科学研究, 2018, 31(4): 669-678. OU Shengju, WU Liping, WANG Xinwu, et al. Chemical characteristics and sources of water-soluble ions of airborne particles during summer in the typical ‘group’ city [J]. Research of Environmental Sciences, 2018, 31(4): 669-678.
[8] 翟慎永, 刘芳盈, 成翔, 等. 淄博市区域空气质量变化对居民呼吸系统健康的影响[J]. 环境与健康杂志, 2016, 33(8): 711-714. ZHAI Shenyong, LIU Fangying, CHENG Xiang, et al. Effects of regional air quality changes on respiratory system health in Zibo, Shandong [J]. Journal of Environment and Health, 2016, 33(8): 711-714.
[9] 刘芳盈, 刘晓利, 张殿平, 等. 2012~2014年淄博市肺癌死亡的空间分析[J]. 预防医学论坛, 2017, 23(8): 575-578. LIU Fangying, LIU Xiaoli, ZHANG Dianping, et al. Spatial analysis on lung cancer mortality, Zibo city, 2012-2014 [J]. Preventive Medicine Tribune, 2017, 23(8): 575-578.
[10] 山东省重点慢性病发病与死亡状况报告(2018)[EB/OL].(2020-12-16)[2021-06-15]. http://wsjkw.shandong.gov.cn/zwgk/fdzdgknr/tjgb/202012/t20201216_3489741.html.
[11] Moran PA. Notes on continuous stochastic phenomena [J]. Biometrika, 1950, 37(1-2): 17-23.
[12] He J, Pan Z, Liu D, et al. Exploring the regional differences of ecosystem health and its driving factors in China [J]. Sci Total Environ, 2019, 673: 553-564. doi: 10.1016/j.scitotenv.2019.03.465.
[13] Liao WB, Ju K, Gao YM, et al. The association between internal migration and pulmonary tuberculosis in China, 2005-2015: a spatial analysis [J]. Infect Dis Poverty, 2020, 9(1): 5. doi: 10.1186/s40249-020-0621-x.
[14] Anselin L. Local indicators of spatial association-LISA [J]. Geogr Anal, 1995, 27(2): 93-115.
[15] Li S, Hu T, Lv W, et al. Changes in prevalence and clinical characteristics of cervical cancer in the Peoples Republic of China: a study of 10,012 cases from a nationwide working group [J]. Oncologist, 2013, 18(10): 1101-1107.
[16] Schiffman M, Castle PE, Jeronimo J, et al. Human papillomavirus and cervical cancer [J]. Lancet, 2007, 370(9590): 890-907.
[17] Dorak MT, Karpuzoglu E. Gender differences in cancer susceptibility: an inadequately addressed issue [J]. Front Genet, 2012, 3: 268. doi: 10.3389/fgene.2012.00268.
[18] Gasperino J. Gender is a risk factor for lung cancer [J]. Med Hypotheses, 2011, 76(3): 328-331.
[19] Ge C, Peters S, Olsson A, et al. Respirable crystalline silica exposure, smoking, and lung cancer subtype risks. a pooled analysis of case-control studies [J]. Am J Respir Crit Care Med, 2020, 202(3): 412-421.
[20] Pukkala E, Martinsen JI, Lynge E, et al. Occupation and cancer-follow-up of 15 million people in five Nordic countries [J]. Acta Oncol, 2009, 48(5): 646-790.
[21] 许文轩, 田永中, 肖悦, 等. 华北地区空气质量空间分布特征及成因研究[J]. 环境科学学报, 2017, 37(8): 3085-3096. XU Wenxuan, TIAN Yongzhong, XIAO Yue, et al. Study on the spatial distribution characteristics and the drivers of AQI in North China [J]. Acta Scientiae Circumstantiae, 2017, 37(8): 3085-3096.
[22] 薛文博, 王金南, 杨金田, 等. 淄博市大气污染特征模型模拟及环境容量估算[J]. 环境科学, 2013, 34(4): 1264-1269. XUE Wenbo, WANG Jinnan, YANG Jintian, et al. Simulation of air pollution characteristics and estimates of environmental capacity in Zibo City [J]. Environmental Science, 2013, 34(4): 1264-1269.
[23] 徐宏伟, 张姗姗, 王海燕, 等. 淄博市临淄区2006-2018年职业病发病情况分析[J]. 中国卫生标准管理, 2019, 10(5): 4-7. XU Hongwei, ZHANG Shanshan, WANG Haiyan, et al. Analysis of the incidence of occupational diseases in Linzi district of Zibo City from 2006 to 2018 [J]. China Health Standard Management, 2019, 10(5): 4-7.
[24] Cumberbatch MGK, Jubber I, Black PC, et al. Epidemiology of bladder cancer: a systematic review and contemporary update of risk factors in 2018 [J]. Eur Urol, 2018, 74(6): 784-795.
[25] Lortet-Tieulent J, Georges D, Bray F, et al. Profiling global cancer incidence and mortality by socioeconomic development [J]. Int J Cancer, 2020, 147(11): 3029-3036.
[26] Welch HG, Fisher ES. Income and cancer overdiagnosis- when too much care is harmful [J]. N Engl J Med, 2017, 376(23): 2208-2209.
[27] Huang Qiaolong, Chen Qin. The effects of PM_2.5 on chronic cardio-cerebrovascular diseases and respiratory diseases in different groups [C]. Journal of Physics: Conference Series, 2021, 1774(1): 012016. doi:10.1088/1742-6596/1774/1/012016.

相关文章 15

[1]	丁小满,吕燕,孙嘉文,赵宝添,亓娜,焦海涛. 2019年3月至2024年2月济南市儿童流感样病例中人鼻病毒流行及基因进化特征[J]. 山东大学学报 (医学版), 2025, 63(7): 102-108.
[2]	王雪梅,杨豪,宋洋,程世超,张婷婷,王艳春. 抗糖尿病药物与女性恶性肿瘤的因果关联:一项两样本孟德尔随机化分析[J]. 山东大学学报 (医学版), 2025, 63(6): 67-77.
[3]	黄馨,王梦雪,付书璠,张琦悦,徐力. 代谢综合征及其组分与消化系统恶性肿瘤的因果关联:两样本孟德尔随机化研究[J]. 山东大学学报 (医学版), 2025, 63(5): 86-94.
[4]	梁珂梦,李树芬,倪志松,宋思豪,席睿,程传龙,左慧,段雨琪,刘昆,白尧,李秀君. 基于MGWR模型的西安手足口病发病影响因素[J]. 山东大学学报 (医学版), 2024, 62(6): 96-101.
[5]	卢伟,刘欢,贾贤杰,苏萍,施婕,王雅倩,迟蔚蔚. 植被覆盖与呼吸系统恶性肿瘤死亡风险关联分析[J]. 山东大学学报 (医学版), 2023, 61(8): 94-100.
[6]	杜圣红,李晓梅,陈晨,王玲. 鼻型弥漫大B细胞淋巴瘤合并肺腺癌1例并文献复习[J]. 山东大学学报 (医学版), 2023, 61(8): 111-115.
[7]	丁小满,刘慧,亓娜,王昕,武伟华,孙颖,吕燕,赵怀龙,赵红,赵宝添,焦海涛,房师松,刘岚铮. 2016年4月—2022年3月深圳市和济南市流感病原学监测及流行特征[J]. 山东大学学报 (医学版), 2023, 61(5): 96-101.
[8]	殷钏杰,陈国玲,康随芳,张琪晨,曹媛,王晓映,张飞雪. 脉络膜黑色素瘤伴视网膜脱离1例并文献复习[J]. 山东大学学报 (医学版), 2023, 61(5): 119-121.
[9]	郑良,孙明浩,石圆,于胜男,王志强,李秀君. 2011—2019年山东省肾综合征出血热时空分布及影响因素[J]. 山东大学学报 (医学版), 2023, 61(11): 104-110.
[10]	王丽慧,高敏,孔北华. 子宫血管肉瘤2例报告并文献复习[J]. 山东大学学报 (医学版), 2022, 60(9): 108-112.
[11]	房启迪,杨淑霞,齐畅,程传龙,韩闯,刘盈,崔峰,李秀君. 基于镇街尺度的淄博市2019年脑卒中时空分布[J]. 山东大学学报 (医学版), 2022, 60(2): 81-88.
[12]	常彩云,于秋燕,赵小冬,王芳,李伟,阮师漫,耿兴义. 济南市首例新型冠状病毒肺炎病例及其相关家庭聚集性疫情分析[J]. 山东大学学报 (医学版), 2020, 58(4): 7-11.
[13]	杨柳,李战,许华茹,常彩云,刘仲,李传彬,孙湛,景睿,刘铁诚,耿兴义,周敬文. 济南市10例儿童新型冠状病毒肺炎确诊病例流行病学和临床特征[J]. 山东大学学报 (医学版), 2020, 58(4): 36-39.
[14]	贾艳,李春雨,刘利利,佘凯丽,刘廷轩,朱雨辰,齐畅,张丹丹,王旭,陈恩富,李秀君. 浙江省新型冠状病毒肺炎的流行特征与空间分析[J]. 山东大学学报 (医学版), 2020, 58(10): 66-73.
[15]	刘廷轩,齐畅,佘凯丽,贾艳,朱雨辰,李春雨,刘利利,王旭,章志华,李秀君. 河北省新型冠状病毒肺炎流行特征与时空聚集性分析[J]. 山东大学学报 (医学版), 2020, 58(10): 74-81.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed