免疫治疗在胚胎反复种植失败中的应用进展

doi:10.6040/j.issn.1671-7554.0.2021.0877

摘要/Abstract

摘要： 胚胎反复种植失败(RIF)是现代生殖医学领域研究的热点和难点问题,其发病因素繁多且复杂。随着生殖免疫学的不断兴起,近年来研究发现,免疫因素在胚胎种植过程中发挥重要作用,有针对性的免疫治疗方法可改善部分患者的妊娠结局。本文主要从RIF免疫因素的发病机制及相关免疫治疗方法的应用进展等方面进行综述,以期为未来的基础研究和临床治疗提供参考。

关键词: 体外受精-胚胎移植, 反复种植失败, 免疫治疗

Abstract: Repeated implantation failure(RIF)is a hot and difficult issue in the field of modern reproductive medicine, with numerous and complex pathogenic factors. With the rise of reproductive immunology, recent studies have found that immune factors play an important role in the process of embryo implantation, and targeted immunotherapy can improve the pregnancy outcome of some patients. This article reviews the pathogenesis of RIF immune factors and the progress in the application of related immunotherapy methods, hoping to provide references for future basic research and clinical treatment.

Key words: In vitro fertilization-embryo transfer, Repeated implantation failure, Immunotherapy

中图分类号:

R392.69

邓晓惠,郭玲. 免疫治疗在胚胎反复种植失败中的应用进展[J]. 山东大学学报 (医学版), 2021, 59(8): 32-37.

DENG Xiaohui, GUO Ling. Applications and progress of immunotherapy in repeated implantation failure[J]. Journal of Shandong University (Health Sciences), 2021, 59(8): 32-37.

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