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山东大学学报 (医学版) ›› 2020, Vol. 1 ›› Issue (7): 82-88.doi: 10.6040/j.issn.1671-7554.0.2020.0261

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胫骨高位截骨术联合自体脂肪间充质干细胞注射在膝关节软骨修复中的应用

李松林1,刘培来1,卢群山1,马贺然2,3   

  1. 1. 山东大学齐鲁医院骨科, 山东 济南 250012;2. 山东省齐鲁细胞治疗工程技术有限公司, 山东 济南 250000;3. 山东银丰生命科学研究院, 山东 济南 250000
  • 出版日期:2020-07-20 发布日期:2020-07-10
  • 通讯作者: 刘培来. E-mail:gklpl@163.com
  • 基金资助:
    山东省重点研发计划(2016GSF201081);山东大学横向课题(12671818)

Application of high tibial osteotomy combined with autologous adipose-derived mesenchymal stem cells injection in the repair of knee cartilage

LI Songlin1, LIU Peilai1, LU Qunshan1, MA Heran2,3   

  1. 1. Department of Orthopaedics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China;
    2. Qilu Cell Therapy Technology Co., Ltd, Jinan 250000, Shandong, China;
    3. Shandong Yinfeng Life Science Research Institute, Jinan 250000, Shandong, China
  • Online:2020-07-20 Published:2020-07-10

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摘要： 目的 探讨胫骨高位截骨术联合自体脂肪间充质干细胞注射对膝关节骨关节炎患者软骨修复的效果。 方法 分析行胫骨高位截骨术联合自体脂肪间充质干细胞注射治疗膝关节骨关节炎患者2例的临床资料,以及术前与术后1年的X线及磁共振(MRI),两次关节镜探查情况,术前与术后1年的疼痛视觉模拟评分及膝关节功能评分,评估此种治疗方式对膝关节软骨修复的效果及膝关节功能的改善情况。 结果 2例患者术前MRI及术中关节镜提示膝关节软骨损伤,行胫骨高位截骨术联合自体脂肪间充质干细胞关节腔注射治疗,术后1年患者膝关节功能恢复良好,行MRI及二期关节镜探查见关节软骨较术前再生。 结论 行胫骨高位截骨术的膝关节骨关节炎患者,联合自体脂肪间充质干细胞注射可有效促进膝关节软骨修复,改善患者膝关节功能。

关键词: 膝关节骨关节炎, 胫骨高位截骨术, 干细胞, 软骨修复, 保膝

Abstract: Objective To evaluate the efficacy of high tibial osteotomy(HTO)combined with autologous adipose-derived mesenchymal stem cells injection on cartilage repair in patients with knee osteoarthritis. Methods The clinical data of 2 patients with knee osteoarthritis treated with HTO combined with autologous adipose-derived mesenchymal stem cells injection were retrospectively analyzed, including preoperative and postoperative 1-year X-ray and MRI data, arthroscopic results, visual analogue score, and knee joint function score, so as to evaluate the effects on knee cartilage repair and knee joint function improvement. Results Preoperative MRI and intraoperative arthroscopy indicated knee cartilage injury in both patients. HTO combined with intra-articular injection of autologous adipose-derived mesenchymal stem cells was performed. Knee joint function recovered well 1 year after operation and articular cartilage regenerated. Conclusion For patients with knee osteoarthritis, HTO combined with autologous adipose-derived mesenchymal stem cells injection can effectively promote the repair of knee cartilage and improve the function of knee joint.

Key words: Knee osteoarthritis, High tibial osteotomy, Stem cells, Cartilage repair, Knee preservation

中图分类号: 

  • R684
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