中国房颤人群心肌组织中MMPs与TIMPs的mRNA表达水平的Meta分析

doi:10.6040/j.issn.1671-7554.0.2014.485

摘要/Abstract

摘要： 目的探讨心肌组织中MMPs、TIMPs的 mRNA表达水平与中国房颤人群的相关性。方法检索2001年1月至2014年5月Pubmed, Web of Science, CNKI和万方数据库已发表文献,研究人群为经心脏外科手术的中国房颤与窦性心律患者,取左右心房或左右心耳的心肌组织,检测MMPs和TIMPs的mRNA表达水平在房颤组与窦性心律组的差别。结果纳入9篇文献,通过荟萃分析发现,MMP-1的mRNA表达水平房颤组较窦性心律组明显增加(SMD=0.48, 95% CI:0.20~0.76, P<0.01)。MMP-9的mRNA表达水平房颤组较窦性心律组明显增加(SMD=1.11, 95% CI:0.75~1.46, P<0.01)。TIMP-1的mRNA表达水平房颤组较窦性心律组无明显差异(SMD=-0.56, 95% CI:-1.77~0.65, P=0.37)。TIMP-2的mRNA表达水平房颤组较窦律组无明显差异(SMD=0.31, 95% CI: -1.16~1.78, P=0.68)。结论心房纤维化在房颤的发生和维持发挥着重要作用,基质金属蛋白酶中MMP-1和MMP-9影响心房的纤维化,其转录水平的升高促进房颤的发生,参与房颤的心房结构重构,而TIMPs在房颤中的作用尚存争议。

关键词: 房颤, 基质金属蛋白酶, 基质金属蛋白酶组织抑制剂

Abstract: Objective To explore the correlation between myocardial MMPs and TIMPs mRNA levels and Chinese with atrial fibrillation (AF). Methods Databases including Pubmed, Web of Science, CNKI and Wanfang were searched up to May, 2014, to retrieve published studies comparing myocardial mRNA levels of MMPs and TIMPs in Chinese AF patients and sinus rhythm (SR) patients, and then a meta-analysis was conducted. The cardiac tissue samples were obtained from patients who underwent cardiac surgery. Results Altogether 9 studies with AF patients and SR controls were included. The MMP-1 mRNA expression was higher in AF patients than in controls (SMD=0.48, 95% CI: 0.20 to0.76, P<0.01). The MMP-9 mRNA expression was higher in AF patients than in controls (SMD=1.11, 95% CI: 0.75 to 1.46, P<0.01). There was no significant difference in the TIMP-1 and TIMP-2 mRNA expressions between AF patients and controls (SMD=-0.56, 95% CI:-1.77 to 0.65, P=0.37), (SMD=0.31, 95% CI:-1.16 to 1.78, P=0.68). Conclusion Atrial fibrosis increases in atrial fibrillation, and the increased transcript levels of MMP-1 and MMP-9 are associated with the occurrence of atrial fibrillation and remodeling of atrial structure. However, the role of TIMPs is still unclear.

Key words: Matrix metalloproteinases, Atrial fibrillation, Tissue inhibitors of matrix metalloproteinases

中图分类号:

R541

张伶俐, 周莹, 李小荷, 李慧, 钟明, 张薇. 中国房颤人群心肌组织中MMPs与TIMPs的mRNA表达水平的Meta分析[J]. 山东大学学报（医学版）, 2015, 53(1): 47-53.

ZHANG Lingli, ZHOU Ying, LI Xiaohe, LI Hui, ZHONG Ming, ZHANG Wei. Myocardial MMPs and TIMPs mRNA expressions in Chinese population with atrial fibrillation: a Meta-analysis[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2015, 53(1): 47-53.

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