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山东大学学报（医学版） ›› 2014, Vol. 52 ›› Issue (8): 75-80.doi: 10.6040/j.issn.1671-7554.0.2014.163

• 临床医学 • 上一篇    下一篇

类风湿关节炎与TNFAIP3基因多态性关联研究的meta分析

王威严1, 杨清锐1, 袁苑2, 杨杏林1, 张源潮1   

  1. 1. 山东大学附属省立医院风湿免疫科, 山东 济南 250021;
    2. 山东大学附属省立医院保健综合科, 山东 济南 250021
  • 收稿日期:2014-03-21 修回日期:2014-07-01 出版日期:2014-08-10 发布日期:2014-08-10
  • 通讯作者: 张源潮。E-mail：qryang720@163.com E-mail:qryang720@163.com
  • 基金资助:
    山东省自然科学基金（ZR2009CM035）；山东省科技发展计划（2011GGH21829）；国家自然科学基金（81172861）

Meta-analysis of TNFAIP3 gene polymorphism with rheumatoid arthritis

WANG Weiyan1, YANG Qingrui1, YUAN Yuan2, YANG Xinglin1, ZHANG Yuanchao1   

  1. 1. Department of Rheumatology and Immunology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China;
    2. Department of Comprehensive Health Care, Provincial Hospital Affiliated to Shandong University, Jinan 250021, Shandong, China
  • Received:2014-03-21 Revised:2014-07-01 Online:2014-08-10 Published:2014-08-10

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摘要： 目的 探讨类风湿关节炎（RA）与TNFAIP3基因多态性的关联性。方法 选择TNFAIP3基因6个位点（rs6920220、rs2230926、rs5029937、rs10499194、rs2327832、rs13207033），检索已发表的RA与TNFAIP3基因多态性关联研究的文献进行Meta分析。结果 18篇文献共纳入27 554例RA患者和39664例正常对照。综合分析显示，TNFAIP3基因rs6920220、rs2230926、rs5029937位点基因多态性与RA存在关联（P<0.00001，P=0.03，P=0.002）；TNFAIP3基因rs2327832和rs13207033位点基因多态性与RA无关联（P=0.27，P=0.05）。亚组分析显示，白种人TNFAIP3基因rs10499194位点基因多态性与RA存在关联[OR=0.87（0.80~0.95），P=0.002]；黄种人TNFAIP3基因rs10499194位点基因多态性与RA存在关联[OR=1.28（1.13~1.46），P=0.000 1]。结论 Meta分析显示，TNFAIP3基因rs6920220、rs2230926、rs5029937位点基因多态性与RA存在关联，rs10499194位点基因多态性与RA的关联有种族差异。

关键词: Meta分析, 类风湿, 关节炎, 肿瘤坏死因子诱导蛋白3, 基因多态性

Abstract: Objective To validate the association between rheumatoid arthritis (RA) and TNFAIP3 gene polymorphism. Methods A total of 6 SNPs in TNFAIP3 (rs6920220, rs2230926, rs5029937, rs10499194, rs2327832, rs13207033) which had been extensively examined were selected. Published studies on RA and TNFAIP3 were retrieved and a Meta-analysis was conducted. Results Altogether 18 studies with 27 554 RA patients and 39,664 controls were included. The comprehensive analysis indicated that the gene polymorphism of rs6920220, rs2230926 and rs5029937 was associated with RA (P<0.000 01, P=0.03, P=0.002). The gene polymorphism of rs2327832 and rs13207033 was not associated with RA (P=0.27, P=0.05). The subgroup analysis revealed that the gene polymorphism of rs10499194 was associated with RA in white people [OR= 0.87 (0.80-0.95), P=0.002]. The gene polymorphism of rs10499194 was associated with RA in yellow people[OR=1.28(1.13-1.46), P=0.000 1]. Conclusion The Meta-analysis reveals that the gene polymorphism of rs6920220, rs2230926 and rs5029937 is associated with RA. The association between the gene polymorphism of rs10499194 and RA has racial differences.

Key words: Rheumatoid, arthritis, Tumor necrosis factor alpha induced protein 3, Polymorphism, Meta-analysis

中图分类号: 

  • R593.22
[1] Harris E D. Rheumatoid arthritis. Pathophysiology and implications for therapy[J]. N Engl J Med, 1990, 322(18):1277-1289.
[2] Ollier W, Thomson W. Population Genetics of rheumatoid arthritis[J]. Rheum Dis Clin North Am, 1992, 18(4):741-759.
[3] Deighton C M, Walker D J, Griffiths I D, et al. The contribution of HLA to rheumatoid arthritis[J]. Clin Genet, 1989, 36(3):178-182.
[4] Vereecke L, Beyaert R, van Loo G. Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease[J]. Biochem Soc Trans, 2011, 39(4):1086-1091.
[5] Lee E G, Boone D L, Chai S, et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice [J]. Science, 2000, 289(5488):2350-2354.
[6] Thomson W, Barton A, Ke X, et al. Rheumatoid arthritis association at 6q23 [J]. Nat Genet, 2007, 39(12):1431-1433.
[7] Plenge R M, Cotsapas C, Davies L, et al. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis [J]. Nat Genet, 2007, 39(12):1477-1482.
[8] Raychaudhuri S, Remmers E F, Lee A T, et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis [J]. Nat Genet, 2008, 40(10):1216-1223.
[9] Han T U, Bang S Y, Kang C, et al. TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians[J]. Arthritis Rheum, 2009, 60(9):2577-2584.
[10] Coenen M J, Trynka G, Heskamp S, et al. Common and different genetic background for rheumatoid arthritis and coeliac disease [J]. Hum Mol Genet, 2009, 18(21):4195-4203.
[11] Stark K, Rovensky J, Blazickova S, et al. Association of common polymorphisms in known susceptibility genes with rheumatoid arthritis in a Slovak population using osteoarthritis patients as controls [J]. Arthritis Res Ther, 2009, 11(3):70.
[12] Dieguez-Gonzalez R, Calaza M, Perez-Pampin E, et al. Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility [J]. Arthritis Res Ther, 2009, 11(2):42.
[13] Perdigones N, Lamas J R, Vigo A G, et al. 6q23 polymorphisms in rheumatoid arthritis Spanish patients [J]. Rheumatology, 2009, 48(6):618-621.
[14] Orozco G, Hinks A, Eyre S, et al. Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23 [J]. Hum Mol Genet, 2009, 18(14):2693-2699.
[15] Hughes L B, Reynolds R J, Brown E E, et al. Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans [J]. Arthritis Rheum, 2010, 62(12):3547-3553.
[16] Shimane K, Kochi Y, Horita T, et al. The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population [J]. Arthritis Rheum, 2010, 62(2):574-579.
[17] Morgan A W, Robinson J L, Conaghan P G, et al. Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort [J]. Arthritis Res Ther, 2010, 12(2):57.
[18] Plant D, Flynn E, Mbarek H, et al. Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers [J]. Ann Rheum Dis, 2010, 69(8):1548-1553.
[19] Ben Hamad M, Cornelis F, Maalej A, et al. A Tunisian case-control association study of a 6q polymorphism in rheumatoid arthritis [J]. Rheumatol Int, 2012, 32(6):1849-1850.
[20] Musone S L, Taylor K E, Nititham J, et al. Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases [J]. Genes Immun, 2011, 12(3):176-182.
[21] Perkins E A, Landis D, Causey Z L, et al. Association of Single-Nucleotide Polymorphisms in CCR6, TAGAP, and TNFAIP3 with Rheumatoid Arthritis in African Americans[J]. Arthritis Rheum, 2012, 64(5):1355-1358.
[22] Zhang X G, Li W, Zhang X P, et al. The association of single nucleotide polymorphisms in TNFAIP3 with rheumatoid arthritis in the Chinese population [J]. Centr Eur J Immunol, 2013, 38(2):214-220.
[23] Kim S K, Choe J Y, Bae J, et al. TNFAIP3 gene polymorphisms associated with differential susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Korean population [J]. Rheumatology, 2014, 53(54):267-271.
[24] Heyninck K, De Valck D, Vanden Berghe W, et al. The Zinc Finger Protein A20 Inhibits TNF-induced NF-kB-dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-kB-inhibiting Protein ABIN [J]. J Cell Biol, 1999, 145(7):1471-1482.
[25] Lee E G, Boone D L, Chai S, et al. Failure to regulate TNF-induced NF-kappaB and celldeath responses in A20-deficient mice [J]. Science, 2000, 289(5488):2350-2354.
[26] 但汉雷, 白杨, 张亚历, 等. Meta分析方法及其医学科研价值与评价[J]. 中华医学科研管理杂志, 2003, 16(01):13-16.
[27] Hah Y S, Lee Y R, Jun J S, et al. A20 suppresses inflammatory responses and bone destruction in human fibroblast-like synoviocytes and in mice with collagen-induced arthritis [J]. Athritis Rheum, 2010, 62(8):2313-2321.
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