关键词: 宫颈肿瘤, 危险因素, 病例对照研究, 条件Logistic回归分析

Abstract: To investigate risk factors of cervical cancer in Shandong Province and to provide a scientific basis for monitoring and preventing this disease. MethodsA 1:2 matched casecontrol study including 893 cases with cervical cancer and 1786 controls was carried out in Shandong Province. Data were analyzed with conditional logistic regression. ResultsBased on monovariate analysis results, multivariate logistic analysis was used. HPV16 infection, HPV52 infection, smoking, age of first intercourse, number of sexual partners, number of induced abortions, spouse with penile cancer or prostatic cancer, postmenopause, and condom usage were selected into the module. The OR value respectively was 28.256, 10.164, 2.946, 0.507, 4.529, 4.012, 4.211, 1.312, 0.507 and 0.612. ConclusionHPV16 and HPV52 infection play important roles in the development of cervical cancer in Shandong Province. Young age at first intercourse, larger number of sexual partners, larger number of induced abortion, smoking and spouse with penile cancer or prostatic cancer are risk factors of cervical cancer. However, postmenopause and condom use are protective factors against cervical cancer.

Key words: cervical neoplasms, risk factor, matched casecontrol study, conditional logistic regression analysis