关键词: 左室肥厚 , 微量白蛋白尿, 转化生长因子β, 血管紧张素Ⅱ, 高血压

Abstract: Objective： To investigate the relationship between the serum level of TGFβ1 and hypertensive target organ damage in patients with essential hypertension(EH). Methods： Eighty-two patients with EH were enrolled and divided into three groups based on the albumin-to-creatinine ratio (ACR): a group with ACR≥300mg/g (group A, n=28), a group with ACR＞30mg/g＜300mg/g (group B, n=31), and a group with ACR≤30mg/g (group C, n=23). Levels of ACR and AngⅡwere determined by radioimmunoassay, and serum TGFβ1 by a sandwich ELISA. The left ventricular telediastolic internal diameter, interventricular septum diastolic, posterior wall thickness, left ventricular mass index and left ventricular ejection fraction were determined by MB mode echocardiography. Results： TGFβ1 level was significantly higher in group A than in groups B and C(P＜0.01), and was also significantly different between group B and C(P＜0.05). TGFβ1 was directly related to ACR，AngⅡ and LVMI, but not related to BMI or blood pressure. Conclusion： TGFβ1, a useful marker plays an important role in the occurrence and progression of hypertensive target organ damage.

Key words: Essential hypertension, Transforming growth factor-beta, Angiotensin, Microalbuminuria, Left ventricular hypertrophy