通心络对自发性高血压大鼠心肌纤维化的作用

山东大学学报(医学版)

通心络对自发性高血压大鼠心肌纤维化的作用

赵学强¹,卜培莉¹，赵玉霞²，王立玲³，李传保¹，郝明秀¹，张运¹

1. 教育部和卫生部心血管重构与功能研究重点实验室山东大学齐鲁医院心内科，济南 250012；2. 山东大学齐鲁医院中医科，济南 250012； 3. 山东省立医院儿科，济南 250021

收稿日期:2007-05-15 修回日期:1900-01-01 出版日期:2007-11-24 发布日期:2007-11-24
通讯作者: 卜培莉

Effect of Tongxinluo on myocardial fibrosis of rats with spontaneous hypertension

ZHAO Xue-qiang¹,BU Pei-li¹，ZHAO Yu-xi²，WANG Li-ling³，LI Chuan-bao¹，HAO Ming-xiu¹，ZHANG Yun¹

1. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health; Department of Cardiology, Qilu Hospital of Shandong University;2. Department of Traditional Chinese Medicine

Received:2007-05-15 Revised:1900-01-01 Online:2007-11-24 Published:2007-11-24
Contact: BU Pei-li

摘要/Abstract

摘要： 目的探讨通心络对自发性高血压大鼠心肌纤维化的作用。方法随机将16只8周龄自发性高血压大鼠(SHR)分为通心络治疗组(TXL)和空白对照组(SHR)各8只,另取8只8周龄雄性Wistar Kyoto大鼠(WKY)作为正常对照组。20周龄时超声二尖瓣口舒张早期与舒张晚期前向血流峰值速度比值(E/A)、左室瓣环处侧壁内膜下心肌舒张早期峰值速度与舒张晚期峰值速度的比值(Ea/Aa)、二尖瓣E峰减速时间(DTe)、左室等容舒张时间(IVRT)，室间隔的平均声学强度(AII1)、峰-峰强度(PPI1)及其心包校正的声学强度(CAI1)，左室后壁的平均声学强度(AII2)、峰-峰强度(PPI2)及其心包校正的声学强度 (CAI2)。结果① TXL组大鼠E/A、Ea/Aa较SHR增大(P＜0.05)，较WKY减小(P＜0.05)；TXL组大鼠DTe、IVRT较SHR缩短(P＜0.05)，较WKY延长(P＜0.05)；②　TXL组大鼠AII1、AII2、CAI1、CAI2较SHR大鼠减小(P＜0.05)，较WKY增大(P＜0.05)；TXL组大鼠PPI1、PPI2较SHR减小(P＜0.05)，较WKY增大(P＜0.05)。结论通心络可抑制压力负荷导致的心肌纤维化,改善心脏舒张功能。

关键词: 高血压 , 通心络, 大鼠, 近交SHR, 纤维化

Abstract: ObjectiveTo explore the effects of Tongxinluo on myocardial fibrosis of rats with spontaneous hypertension. Methods16 eight-week-old male rats with spontaneous hypertension (SHRs) were divided at random into two groups: the Tongxinluo group (n=8, 1.5mg·kg^-1·d^-1) and the SHR group(n=8). Another 8 eight-week-old male Wistar Kyoto rats served as the control group. 12 weeks later, the ratio of early to late mitral flow, the ratio of early to late mitral annulus velocity (E/A and Ea/Aa), the deceleration time of the E wave (DTe), the left ventricular isovolumic relaxation time (IVRT), the average image intensity (AII), the corrected acoustic intensity (CAI) and the peak to peak intensity (PPI) of the interventricular septum and the left ventricular posterior wall were all determined by cardiography. Results① The diastolic indexes E/A and Ea/Aa in the Tongxinluo group were SHR group(P＜0.05), but were significantly lower than those in the normal control group (P<0.05); the diastolic indexes DTe and IVRT in the Tongxinluo group were significantly higher than those in the SHR group (P＜0.05), but were significantly lower than those in the control group (P＜0.05). ② AII and CAI of the inter-ventricular septum and the left ventricular posterior wall in the Tongxinluo group were significantly lower than those in the SHR group, but PPI of the inter-ventricular septum and the left ventricular posterior wall was significantly higher than that in the SHR group (P＜0.05); AII and CAI of the interventricular septum and the left ventricular posterior wall in the control group were significantly lower than those in the Tongxinluo group, but PPI of the inter-ventricular septum and the left ventricular posterior wall was significantly higher than that in the Tongxinluo group (P＜0.05). Conclusion Tongxinluo capsule can reduce myocardial fibrosis caused by overload and improves the left ventricular diastolic dysfunction induced by hypertension.

Key words: Fibrosis, Rats Inbred SHR, Tongxinluo, Hypertension

中图分类号:

R541.3

赵学强,卜培莉,赵玉霞,王立玲,李传保,郝明秀,张运 . 通心络对自发性高血压大鼠心肌纤维化的作用[J]. 山东大学学报(医学版), 2007, 45(11): 1117-1121.

ZHAO Xue-qiang,BU Pei-li,ZHAO Yu-xi,WANG Li-ling,LI Chuan-bao,HAO Ming-xiu,ZHANG Yun. Effect of Tongxinluo on myocardial fibrosis of rats with spontaneous hypertension[J]. JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES), 2007, 45(11): 1117-1121.

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