Abstract: Objective: To explore the effect of percutaneous embolization of gastroesophageal varices, with TH glue as the embolus, combined with partial splenic embolization(PTVE+PSE) and pericardical devascularization plus splenectomy in the treatment of portal hypertension. Methods: A total of 147 cases were divided into two groups: 75 cases in the intervention group (PTVE+PSE) and 72 cases in the operation group. The incidence of re-bleeding, death, gastroesophageal revarices, the improvement of splenemagly and the complications were observed in the two groups. Results: All procedures and operations were successful. At the beginning of the five-year follow-up, there were no differences in the mortality and re-bleeding, and the improvement of splenemagly was remarkable in both groups. With time, the rate of re-bleeding and gastroesophageal variceal in the operation group was higher than that of the intervention group. Also, the complications in the operation group were more serious than that in the intervention group during perioperation, which increased the cost and time in hospital. Conclusion: With TH glues as the embolus, PTVE combined with PSE is safe, reasonable and effective for gastroesophageal varices. This treatment is able to replace pericardial devascularization plus splenectomy.

Key words: Portal hypertention, Gastroesophageal varices, TH glue, percutaeous transhepatic variceal embolization, Partial splenic embolization devascularization, Splenectomy