JOURNAL OF SHANDONG UNIVERSITY (HEALTH SCIENCES)

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Effects of valsartan and low molecular weight heparin on the growth of glomeruli mesangial cells stimulated by high glucose

WANG Yun-shan1， LIU Fang-e2， JIAO Bo1   

  1. 1. Department of Pharmacology, School of Pharmacy, Shandong University, Jinan 250012, Shandong, China；2. Department of Pediatrics, Second Hospital of Shandong University, Jinan 250033, Shandong, China
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-04-24 Published:2007-04-24
  • Contact: WANG Yun-shan

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Abstract: Objective：To observe the effect of valsartan and low molecular weight heparin on the proliferation of glomeruli mesangial cells stimulated by high glucose. Methods：Mesangial cell line was treated by valsartan and low molecular weight heparin in different concentration and time, the proliferation activity was measured by MTT. Results：Both valsartan and low molecular weight heparin could inhibit the proliferation of mesangial cells significantly, and when combined the effect was intensified. Conclusion：The result suggests that the inhibition on mesangial cells is intensified when combined valsartan with low molecular weight heparin, compared with single dose.

Key words: Valsartan, Dalteparin, Mesangical cell, Hyperglycemia

CLC Number: 

  • R587.2
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