Abstract: To estimate the value of ultrafine particle of Leeches on acute brain infarction disease. Methods: A total of 63 cases of early brain infarction disease were divided into 3 groups： group A，treated with normal medicine； group B， treated with normal medicine and bigger particle of Leeches；group C ， treated with normal medicine and ultrafine particle of Leeches. The clinical symptom before and after treatment was observed, and also the level of blood Von Wille brand factor(vWF), pselection(GMP140) were observed. Results: The total response rate of group C and B was higher than that of group A(P<0.01, 0.05). The curative and marked response rates of group C were higher than those of group B(P<0.05). The improvement of blood vWF, GMP140 of group C was better than that of group B(P<0.05,0.01); and that of group B was better than group A(P<0.05, 0.01). Conclusion: There are serious vascular endothelium injury, platelet activity in both brain infarction patients. Ultrafine particle of Leeches is more effective in treating brain infarction disease than bigger particle of Leeches, and it is more effective in improving the blood levels of vWF, GMP140.

Key words: Brain infarction, Leeches, Von Wille brand factor, pselection