Abstract: To prepare and evaluate the quality of Picamilon sodium dispersible tablets. Methods: Different disintegrants were screened and the best formulation was optimized by orthogon experiment design using the disintegration time as index, and the best formulation of Picamilon sodium dispersible tablets was authenticated by the initial stability experiment. Results: The best formulation of Picamilon sodium dispersible tablets was composed of Picamilon sodium 50mg, brushite 120?mg, Ldisplacehydroxypropyl cellulose and sodium carboxymethyl starch 16mg and 2% polyvidone k30 queous solution quantity sufficient. The effect of disintegration was very optimized, Ldisplacehydroxypropyl cellulose and sodium carboxymethyl starch were used in coordination with exterior addition and interior addition. The result showed that the disintegration time of optimized prescription formulation was 95s, and the dissolution percent at 10min of it was obviously super to that of the conventional tablets（P＜0.05）, and the quality of the dispersible tablets was very well by stability test. Conclusion: The dispersible tablets of Picamilon sodium have a higher dissolution speed than conventional tablet.

Key words: Picamilon sodium, Dispersible tablets, Orthogonal design, Disintegration time